Enzymology

Researcher Name: Leung, Ivanhoe

Research Area(s): Enzymology

Affiliation: The University of Melbourne

Country: Australia

Website 

Scientific Interests:

Metabolic regulation of protein functions

The ability to maintain homeostasis is critical to all forms of life. One mechanism through which this is achieved is the fine-tuning of cellular enzyme activities. In our group, we study how posttranslational modifications and metabolites affect the structure, activity and function of proteins and enzymes. These allow us to understand how different biochemical pathways signal and interact with one another to maintain stability in response to stress conditions. We are currently studying the enzymes that are involved in the regulation of carbon metabolism in Mycobacterium tuberculosis to understand how the pathogen survives inside the infected host with limited nutrients. Another system that we are studying is the plant ethylene-forming enzyme. We are presently investigating the mechanisms and structures of the different enzyme isoforms with a view to developing a detailed understanding of their roles in plant growth and development. We apply a range of biophysical, chemical biology and structural biology techniques to enable our discoveries.

This offer applies to trainees/researchers eligible for the following fellowships

PROBio-Africa Fellowships, IUBMB Wood-Whelan Research Fellowships, IUBMB Early-Career Research Fellowships, IUBMB Relocation Support for Displaced Trainees

Contact:

ivanhoe.leung@unimelb.edu.au