Donate nowThe following researchers/laboratories are open to host an IUBMB research fellowship holder. Note that fellows can also choose to go to laboratories not listed on this page.
If you are a researcher interested in becoming a host, please use the following form:
Researcher Name: Mitola, Stefania (She / Her)
Research Area(s): Molecular Bases of Disease
Affiliation: Università degli Studi di Brescia
Country: Italia
Scientific Interests:
Extracellular matrix (ECM) in tumors is recognized as an important driver of cancer cell aggressiveness. On the other hand, it is less known how tumor-derived extracellular matrix mechanically influences angiogenesis, tumor growth and dissemination. Using a syngeneic model of melanoma cells, we study how endothelial cells respond to the changes and remodeling of the tumoral ECM in vitro and in vivo. Remodeled ECM modulates intracellular mechano-trasducion signaling which in turn modulates the metabolic behavior both of tumor and endothelial cells. To this, label-free and high-resolution fluorescence microscopies are used to visualize the 3D structure and remodeling of the ECM in vitro and in vivo systems and to study how the ECM remodeling affects intracellular mechano- and biochemical- signal transduction (e.g. mechanical forces across focal adhesion plaques, ROS production, Calcium fluxes, diffusion of transmembrane proteins along cell membrane). Also, FRAP/FRET/FLIM-FRET technologies are used to characetrize protein-protein interactions and protein dynamics.
This offer applies to trainees/researchers eligible for the following fellowships
All fellowships (not restricted to fellowship holders)
Contact:
stefania.mitola@unibs.it
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International Union of Biochemistry and Molecular Biology