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EMBO Workshop | The epitranscriptome

October 28 to October 30

EMBL

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This conference will take place at EMBL Heidelberg, with the option to attend virtually.

 

Conference Overview

The regulation of the transcriptome is key to cellular processes that underpin cell biology, development, and tissue function. All classes of cellular RNA are subject to post-transcriptional modification, be it by direct chemical modification, editing, or non-templated nucleotide additions. Now, in its fourth edition, ‘The epitranscriptome’ meeting first held at EMBL in 2016 (and repeated in 2018, then in 2022 as a virtual conference) was the first RNA modification-dedicated meeting with a focus on mammalian systems. It is now established that biochemical modifications of nucleotides regulate RNA metabolism, modulate cell functions and contribute to severe human diseases including cancer and metabolic disorders. Moreover, the power of single, chemically modified nucleotides to alter the electrostatic charge, base pairing, and stability of RNA molecules is exploited for clinical use of stable artificial RNA transcripts such as mRNA vaccines or synthetic small RNA molecules to increase or decrease the expression of therapeutic proteins. The 2025 meeting will highlight recent developments and focus on future aspects and current challenges in the field:

  • Critical evaluation of novel methods quantifying RNA modifications at single-nucleotide resolution – with a focus on RNA modification direct sequencing.
  • Biosynthetic mechanism of native and synthetic RNA modifications – implications for therapeutic use.
  • Epitransriptomic regulation mediated by RNA modifications during gene expression and signalling.
  • Novel metabolic pathways requiring RNA modifications to respond to changes in the microenvironment.
  • RNA modifications as prognostic marker in disease.

Together, these basic science discoveries have unravelled the molecular and cellular functions of RNA modifications, have provided new prospects for therapeutic manipulation and have led to a range of innovative clinical approaches. Our program will bring together field-leading experts from across the globe to provide cost-effective access to European researchers to the state-of-the-art.

 

Session topics

  • RNA modification I (m6A)
  • RNA modifications in stem cells and development
  • RNA modification II (m5C, m1A, 3’ terminal additions, etc)
  • RNA modification pathways in physiology and pathology
  • Emerging concepts

Register interest  

#EMBLEpitrans

Details

Start:
October 28
End:
October 30
Event Category:
Website:
https://www.embl.org/about/info/course-and-conference-office/events/ETC25-01/

Venue

EMBL Heidelberg and Virtual
EMBL Advanced Training Centre + Google Map

Organizers

Michaela Frye, Germany
Tsutomiu Suzuki, Japan
Chengqi Yi, China