IUBMB Journals

IUBMB Journal Highlights

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!

 


IUBMB Life

New Issue: Volume 73, Issue 4IUBMB life cover

Issue Highlights

The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies

The latest advances in the sequencing methods in head and neck squamous cell carcinoma (HNSCC) tissues have revolutionized our understanding of the disease by taking off the veil from the most frequent genetic alterations in the components of the oncogenic pathways. Among all the identified alterations, aberrancies in the genes attributed to the phosphoinositide 3‐kinases (PI3K) axis have attracted special attention as they were altered in more than 90% of the tissues isolated from HNSCC patients. In fact, the association between these aberrancies and the increased risk of cancer metastasis suggested this axis as an “Achilles Heel” of HNSCC, which may be therapeutically targeted. The results of the clinical trials investigating the therapeutic potential of the inhibitors targeting the components of the PI3K axis in the treatment of HNSCC patients, either alone or in a combined‐modal strategy, opened a new chapter in the treatment strategy of this malignancy. The present study aimed to review the importance of the PI3K axis in the pathogenesis of HNSCC and also provide a piece of information about the breakthroughs and challenges of PI3K inhibitors in the therapeutic strategies of the disease.

PI3K_Akt_mTORC

 
Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease

Mutations in the novel coronavirus SARS‐CoV2 are the major concern as they might lead to drug/vaccine resistance. In the host cell, the virus largely depends on the main protease (Mpro) to regulate infection hence it is one of the most attractive targets for inhibitor design. However, >19,000 mutations in the Mpro have already been reported. The mutations encompassing 282 amino acid positions and these “hotspots” might change the Mpro structure, activity and potentially delay therapeutic strategies targeting Mpro. Thus, here we identified 24 mutational “coldspots” where mutations have not been observed. We compared the structure‐function relationship of these coldspots with several SARS‐CoV2 Mpro X‐ray crystal structures. We found that three coldspot residues (Leu141, Phe185, and Gln192) help to form the active site, while seven (Gly2, Arg4, Tyr126, Lys137, Leu141, Leu286, and Leu287) contribute to dimer formation that is required for Mpro activity. The surface of the dimer interface is more resistant to mutations compared to the active site. Interestingly, most of the coldspots are found in three clusters and forms conserved patterns when compared with other coronaviruses. Importantly, several conserved coldspots are available on the surface of the active site and at the dimer interface for targeting. The identification and short list of these coldspots offers a new perspective to target the SARS‐CoV2 Mpro while avoiding mutationbased drug resistance.

mutation resistance coldspots

 

SPECIAL ISSUE CALL FOR PAPERS

Inflammation: mechanism, disease, and therapy IUBMB life cover

GUEST EDITORS:   Yi-Ching Wang (National Cheng Kung University) and Chih-Peng Chang (National Cheng Kung University)
 
Manuscripts should be submitted by 31 May 2021
Expected issue publication will be October 2021
 
 
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Biological Responses to Stressor IUBMB life cover

GUEST EDITORS:   Nesrin Kartal Ozer (Marmara University), Jose Vina (University of Valencia), Gloria Olaso (University of Valencia), Erdi Sozen (Marmara University)
 
Manuscripts should be submitted by 31 May 2021
Expected issue publication will be November 2021
 

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Autophagy in Health and Disease IUBMB life cover

GUEST EDITOR:   Ruey-Hwa Chen (Institute of Biological Chemistry, Academia Sinica, Taiwan)
 
Manuscripts should be submitted by 10 September 2021
Expected issue publication will be February 2022
 
 
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                                  Multicellular Microenvironment Effects on the Modulation of Cell Functions IUBMB life cover

GUEST EDITOR:   Xiangya Ding, Nanjing Medical University
 
Manuscripts should be submitted by 30 September 2021
Expected issue publication will be early 2022
 
 
 
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                                  Extracellular Matrix: The Dynamic Structural and Functional Network in Health and Disease IUBMB life cover

GUEST EDITORS:   Nikos Karamanos (Univ. of Patras), Sylvie Ricard-Blum (Univ. of Lyon), Dimitris Kletsas (NCSR Demokritos, Athens)
 
Manuscripts should be submitted by 31 October 2021
Expected issue publication will be March 2022
 
 
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NEW VIRTUAL ISSUES

See all the new IUBMB Life Virtual Issues here

 


BioFactors

Biofactors coverNew Issue: Volume 47, Issue 1

Issue Highlights

Specialized proresolving mediators in infection and lung injury

The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective

Mangiferin and organ fibrosis: A mini review

 


Biotechnology and Applied Biochemistry

Volume 68, Issue 1Biotechnology and Applied Biochemistry

Efficient enzymatic synthesis of cephalexin in suspension aqueous solution system

Overexpression, overproduction, purification, and characterization of rhGH in Escherichia coli

 


Biochemistry and Molecular Biology Education

New Virtual Issue on Teaching in the Time of COVID-19Biochemistry and Molecular Biology Education

Volume 49, Issue 2

Issue Highlights

Introducing climate change into the biochemistry and molecular biology curriculum

BarcodingGO: A problem‐based approach to teach concepts related to environmental‐DNA and bioinformatics

 


Did you know? Wiley and Jisc just signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA.

Submit your research to the IUBMB Journals today.


Molecular Aspects of Medicine

Molecular Aspects of Medicine cover

Volume 74 (2020) 100894
 
The Atlas of Inflammation Resolution (AIR)

Congratulations to our IUBMB Fellows of 2020

CONGRATULATIONS to our latest Wood-Whelan Fellows, from Argentina, Benin, and Spain, who have received fellowships to travel to a lab in a different country for 4 months. We wish them much success in their research!

 
 

CONGRATULATIONS to our latest Mid-Career Fellows, from Argentina, India, and Nigeria, who have received fellowships to travel to a lab in a different country for up to 2 months. We wish them much success in their research!

Inaugural IUBMB Whelan Young Investigator Award

We are also delighted to announce that the inaugural award will be presented to Élyse Fischer, a Gates Cambridge PhD Scholar in the MRC Laboratory of Molecular Biology, University of Cambridge, in the laboratory of Professor David Barford. Her research is directed towards understanding the molecular mechanisms of spindle assembly checkpoint (SAC) activation using a variety of structural and biochemical techniques. Elyse also happens to be the grand daughter of Bill Whelan’s lifelong friend, biochemist Edmond Fischer, who received the Nobel Prize for reversible phosphorylation.

Elyse will be presenting her research at the IUBMB Whelan Young Investigator talk at the Young Scientists Program in Vimeiro, Portugal, 6th to 9th July 2022 directly preceding the 25th IUBMB Congress/FEBS/PAPMB meeting in Lisbon, July 9th-14th, 2022.
 
Elyse Fischer Whelan Award

2020 Wiley-IUBMB Life Young Investigator Prizes & Wiley BioFactors Young Investigator Award

Biji Chatterjee

View the Article

Congratulations to Dr. Biji Chatterjee, whose paper was selected for the Wiley-BioFactors Young Investigator Award. Biji received her PhD in Biochemistry from Central University of Kerala, India.

 
 

Sahar Sadegh-Nejadi

View the Article

Congratulations to Sahar Sadegh-Nejadi, whose paper was selected for the Wiley-BIUBMB Life Young Investigator Award. Sahar is a PhD student in clinical biochemistry at Tehran University of Medical Sciences.