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IUBMB Journals

IUBMB Journal Highlights | October 2024

Posted on | by Charysse Austria
IUBMB Journals
Wiley Logo

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!
• Disease causing gene mutations
• Human Genetic Disorders
• Therapeutic strategies targeting disease-associated mutations

IUBMB Life
New Issue: Volume 76, Issue 10

Issue Highlights (Open Access)

Functional and biochemical characterisation of remote homologues of type IV pili proteins PilN and PilO in Helicobacter pylori

Bonny SQ, Zhou X, Khan MF, Rahman MM, Xin Y, Vankadari N, et al. IUBMB Life. 2024; 76(10): 780–787.

Helicobacter pylori encodes homologues of PilM, PilN and PilO from bacteria with Type IV pili, where these proteins form a pilus alignment complex. Inactivation of pilO changes H. pylori motility in semi-solid media, suggesting a link to the chemosensory pathways or flagellar motor. Here, we showed that mutation of the pilO or pilN gene in H. pylori strain SS1 reduced the mean linear swimming speed in liquid media, implicating PilO and PilN in the function, or regulation of, the flagellar motor. We also demonstrated that the soluble variants of H. pylori PilN and PilO share common biochemical properties with their Type IV pili counterparts which suggests their adapted function in the bacterial flagellar motor may be similar to that in the Type IV pili.

Issue Highlights (Subscription Only)

The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells

Wang H, Li J, Yu K, Lu Y, Ma M, Li Y. IUBMB Life. 2024; 6(10): 764–779.

The Angiomotin (AMOT) family includes AMOT, AMOTL1, and AMOTL2, with AMOTL2 being expressed in endothelial, epithelial, and cancer cells. AMOTL2 localizes differently across cell types, regulating tube formation, cell polarity, and shape. In cancer, its role varies: AMOTL2 promotes tumor growth in pancreatic, breast, and colon cancers but inhibits proliferation in lung, liver, and glioblastoma. It influences cytoskeletal dynamics and modulates YAP transcription by binding to it. AMOTL2 is downregulated in some tumors but elevated in colorectal adenocarcinoma (COAD), where it drives oncogenic activity by affecting the Wnt pathway and immune cell infiltration. Further research is needed to clarify its roles in various cancers.

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SPECIAL ISSUES OPEN FOR SUBMISSION

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

  • A short title that can clearly describe the scope of special issue;
  • A short introduction about the significance of the special issue;
  • Basic information and CV of Lead Guest Editor and Co-Guest Editors;
  • List of potential authors and their tentative article titles;
  • The estimated number of submissions;
  • Proposed timeline.

Please visit the journal homepage for more information.

BioFactors
New Issue: Volume 50, Issue 5

Issue Highlights (Open Access)

Vitamin D metabolism is altered during aging alone or combined with obesity in male mice

Bournot L, Payet T, Marcotorchino J, Awada M, Rouquet T, Breniere T, et al. BioFactors. 2024; 50(5): 957–966.

Aging and obesity are associated with a decrease in plasma 25-hydroxyvitamin D (25(OH)D) levels. In the context of a growing aging population and the rising incidence of obesity, the authors hypothesized that aging process, either independently or in combination with obesity, could influence vitamin D (VD) metabolism, consequently resulting in the reduced 25(OH)D plasma concentrations. The findings of the authors support the notion that aging alone or combined with obesity, induces regulation of VD metabolism in the organs, beyond the classical reduction of epidermal VD precursor, which may contribute to the decrease in 25(OH)D levels.

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

Bhale AS, Meilhac O, d’Hellencourt CL, Vijayalakshmi MA, Venkataraman K. BioFactors. 2024; 50(4): 50(5): 922–956.

High-density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and inflammation modulation. The proteome of HDL particles is indeed complex and distinct from other components in the bloodstream. Proteomics studies have identified nearly 285 different proteins associated with HDL; however, this review focuses more on the 15 or so traditionally named “apo” lipoproteins. Understanding the nature of all 15 apolipoproteins expands our knowledge of HDL metabolism, sheds light on their pathological implications, and paves the way for advancements in the diagnosis, prevention, and treatment of lipid and inflammatory-related disorders.

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CALL FOR PAPERS

Uncovering biomarkers in the tumor-immune microenvironment and analyzing their potential regulatory mechanisms

Submission deadline: Sunday, 30 March 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

  • A short title that can clearly describe the scope of special issue.
  • A short introduction about the significance of the special issue.
  • Basic information and CV of Lead Guest Editor and Co-Guest Editors.
  • List of potential authors and their tentative article titles.
  • The estimated number of submissions.
  • Proposed timeline.

Please visit the journal homepage for more information.

Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 4

Issue Highlights (Open Access)

Waste cooking oil and molasses for the sustainable production of extracellular lipase by Saitozyma flava

Donzella S, Fumagalli A, Contente ML, Molinari F, Compagno C. Biotechnol Appl Biochem. 2024; 71: 712–720.

Organic waste valorization is one of the principal goals of the circular economy. Bioprocesses offer a promising approach to achieve this goal by employing microorganisms to convert organic feedstocks into high value products through their metabolic activities. In this study, a fermentation process for yeast cultivation and extracellular lipase production was developed by utilizing food waste. Lipases are versatile enzymes that can be applied in a wide range of industrial fields, from detergent, leather, and biodiesel production to food and beverage manufacturing. The production medium was composed of molasses, a by-product of the sugar industry, which provided nutrients for yeast biomass formation. At the same time, waste cooking oil was employed to induce and enhance extracellular lipase production.

Correlation between plasma PSGL-1 and FIGO stage, tumor metastasis, and survival in epithelial ovarian cancer

Li WH, Fang C, Gao Y, Gao Y, Yan FS, Chen B, et al. Biotechnol Appl Biochem. 2024; 71: 733–740.

Plasma circulating P-selectin glycoprotein ligand-1 (PSGL-1) levels and its clinical correlation in patients with epithelial ovarian cancer (EOC) are unknown. The study determined plasma PSGL-1 levels in EOC patients and investigated its relationship with clinicopathological factors and prognosis. Plasma PSGL-1 levels were measured using ELISA in 69 patients with EOC, 34 patients with benign ovarian cystadenoma, and 36 healthy controls. Subsequently, the relationship between PSGL-1 levels and clinicopathological characteristics of patients, as well as the prognosis of EOC patients, was examined. Additionally, the specificity and sensitivity of plasma PSGL-1 were assessed through ROC curve analysis.

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CALL FOR PAPERS

Leveraging Genomics Data in Blockchain for Medical Research Ethics

The Special Issue aims to create a dialogue on leveraging genomics data in blockchain for medical research ethics. Also, we plan to attract researchers with a diverse range of studies that explore theoretical frameworks, technological innovations, policy analyses, and case studies demonstrating practical applications and challenges.

Topics for this call for papers include but are not restricted to:

  • Ethical frameworks for genomic data ownership and sharing on blockchain platforms;
  • Technological advancements in secure and scalable blockchain systems for genomic data;
  • Interoperability challenges and solutions in integrating genomics with different blockchain architectures;
  • Regulatory landscape and policy recommendations for blockchain in genomics;
  • Economic models for incentivizing the sharing of genomic data on blockchain platforms;
  • Impact assessments of blockchain on the speed and efficacy of medical research;
  • Legal implications of decentralized genomic data management;
  • Ethical considerations in the use of smart contracts for genomic data consent management;
  • Comparative analyses of global initiatives employing blockchain for genomics;
  • Challenges and strategies for educating stakeholders about the benefits and risks of blockchain in genomics;
  • Future prospects of integrating artificial intelligence with blockchain and genomics for advanced medical research;
  • Privacy-preserving techniques for genomic data on blockchain: challenges and future directions;
  • Case studies of blockchain applications in enhancing privacy and consent in genomics research.

Deadline for Submissions: 1 December 2024

Guest Editors: Dr Muzammil Hussain (Lead), Pakistan; Dr Muhammad Adnan Khan, Gachon University, The Republic of Korea; Dr Kiran Adnan, Malaysia

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Emerging Techniques and Technologies in Healthcare

The purpose of the special issue is to decipher the importance of ground-breaking techniques incorporated in cellular and molecular biology and embrace AI augmented healthcare delivery system. The convergence of these scientific innovations would help translational research reach new heights in the future generation.

Topics for this call for papers include but are not restricted to:

  • Importance of Emerging Techniques and Technologies in Health Research
  • Genetics and Genomics in Healthcare Research
  • Application of Proteomics in Healthcare Research
  • Technological Advancements in Cell Biology for Health Research
  • Artificial Intelligence in Transforming Medicinal Practice
  • Machine Learning and Deep Learning in Healthcare
  • Molecular techniques in Disease Detection
  • Biochemical parameters for disease detection
  • Infectious Disease and Mitigation
  • Stem Cell Therapeutics
  • Ethical Concerns in Artificial Intelligence Mediated Healthcare Delivery

Deadline for Submissions: 15 May 2025

Guest Editors: Dr. Debasmita Bhattacharya, Institute of Engineering and Management, India; Dr. Dibyajit Lahiri, University of Engineering & Mangement, Kolkata, India; Assoc. Prof. Edinur Hisham Atan, Universiti Sains Malaysia, Malaysia; Prof. Mojgan Rezvani, Durham College, Canada.

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Searching for a New Editor-in-Chief for Biotechnology and Applied Biochemistry

The International Union of Biochemistry and Molecular Biology (IUBMB) seeks a new Editor-in-Chief for Biotechnology and Applied Biochemistry. Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of discoveries in the life sciences that impact and advance biotechnology. The Editor will consider papers for publication based on their potential impact on the field, and their compatibility with journal scope. The journal seeks contributions to the fields of synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology, and how they can be applied to medical and industrial biotechnology.

The successful candidate will be recognized as a leading member of the biochemistry and molecular biology community. They will have an outstanding publication record; an extensive, global network; an appreciation for the diverse fields within the journal’s scope; and will represent the diversity within the IUBMB global community.

The successful candidate will have an outstanding opportunity to further develop the journal over a maximum three 3-year terms in the role commencing July 1, 2025. They must demonstrate a clear vision for its future growth and position in the publishing landscape. The appointee will bring extensive experience in peer review and/or editorial roles, high ethical professional standards, innovation, enthusiasm, strong leadership, and organizational and communication skills to the journal.

The main functions within this role are: strategic and practical development of the journal, defining a vision for the content; defining content and commissioning papers for regular and special issues; maintaining editorial standards; providing strong and inspiring leadership to the journal’s editorial board; appointing new board members to grow the journal; promoting the journal; managing the publication, and working closely with IUBMB and the publisher (Wiley). This important leadership role will require a significant time commitment on a weekly basis and will be recompensed accordingly. Associate Editors are appointed to limited terms by the Editors-in-Chief to handle some functions, subject to approval by the IUBMB Executive Committee. The Editor-in-Chief of Biotechnology and Applied Biochemistry will receive an annual honorarium and is supported by professional editorial office assistance.

Applications should include the following

  1. A full CV, including details of peer review and/or editorial roles and the applicant’s publication record
  2. A brief statement describing your vision for Biotechnology and Applied Biochemistry
  3. A cover letter outlining your suitability for the Editor-in-Chief role
  4. Two reference Letters

Please send any queries relating to this appointment and applications, in confidence, to: Prof. James Murphy (jamesm@wehi.edu.au), Chair of the IUBMB Publications Committee. Application deadline October 31, 2024.

Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 5

Issue Highlights (Open Access)

A cost-effective enzyme kinetics and inhibition model for biochemistry education and research

VanDee L, Teague A, East T, Jacinto KR, Carter M, Totty J, et al. Biochem Mol Biol Educ. 2024; 52(5): 588–598.

Enzyme kinetics and inhibition studies are crucial in biochemistry education and research. Conventional methods often require expensive equipment and reagents, potentially limiting their accessibility in limited resource settings. Our approach sought to develop a cost-effective experimental design for studying enzyme kinetics and inhibition. Lactase was chosen as a protein model and its activity was investigated by measuring glucose production from lactose hydrolysis. In the study, commercially available lactase pills were used as an enzyme source, while milk was used as a substrate. Instead of scientific equipment, glucometers were used to measure lactase activity. Enzyme kinetics were evaluated using Michaelis–Menten and Lineweaver–Burk plots. In the study, the effects of temperature, pH, and inhibitors were also investigated. The approach presented here offers a cost-effective procedure for studying enzyme kinetics and inhibition. It can act as a valuable tool for educational purposes and for preliminary research in settings with limited resources.

Enhancing teaching effectiveness in biochemistry labs: Author reflections and improvement strategies

Costabile M, Simpson B, Turkanovic J, Hughes BP. Biochem Mol Biol Educ. 2024; 52(5): 559–568.

This article details the outcome of a joint reflective approach undertaken by the authors to identify common difficulties experienced by 2nd-year undergraduate Biochemistry students in laboratory classes. Difficulties experienced in laboratories can affect the development of hand skills, an understanding of how to correctly operate laboratory equipment and the linkage between didactic content and their experimental demonstration. These difficulties covered were identified based on their common appearance across multiple cohorts and are grouped into five broad areas. The approach and resources developed to address these difficulties may help other Biochemistry educators who are facing similar experiences with their undergraduate students.

Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

Elsevier logo

Molecular Aspects of Medicine

Molecular Aspects of Medicine

Volume 97 (June 2024) 101273
Obesity and male fertility disorders

Rossella Cannarella, Andrea Crafa, Roberto Curto, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero

Volume 97 (June 2024) 101271
Biomarkers of frailty

Mariam El Assar, Isabel Rodríguez-Sánchez, Alejandro Álvarez-Bustos, Leocadio Rodríguez-Mañas

Aspects of Molecular Medicine

Aspects of Molecular Medicine LOW RES for overprint placement

Volume 4 (December 2024) 100052
Patient-related factors drive high rates of reported antibiotic allergies: A qualitative study

Renee Berry, Susan Herrmann, Michaela Lucas

Volume 4 (December 2024) 100046

Genome-wide linkage and association of novel genes and pathways with type 2 diabetes in Italian families

Mutaz Amin, Claudia Gragnoli

IUBMB Journals

IUBMB Journal Highlights | August 2024

Posted on | by Charysse Austria
IUBMB Journals
Wiley Logo

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!
• Disease causing gene mutations
• Human Genetic Disorders
• Therapeutic strategies targeting disease-associated mutations

IUBMB Life
New Issue: Volume 76, Issue 8

IUBMB-Life-v76.8

Issue Highlights (Open Access)

Mitochondrial respiratory supercomplexes of the yeast Saccharomyces cerevisiae

Eldeeb MH, Camacho Lopez LJ, Fontanesi F. IUBMB Life. 2024; 76(8): 485-504.

The functional and structural interplay among components of the mitochondrial respiratory chain is crucial to understanding aerobic catabolism. For over 50 years, it has been debated how individual respiratory enzymes form higher-order structures called respiratory supercomplexes, an evolutionarily conserved feature of the mitochondrial respiratory chain. This review explores the evidence on the functional roles of yeast respiratory supercomplexes, models of complex III and IV assembly, and the possible cross talk between their biogenetic processes.

Evolution and variation in amide aminoacyl-tRNA synthesis

Lewis AM, Fallon T, Dittemore GA, Sheppard K. IUBMB Life. 2024; 76(8): 505-522.

The amide proteogenic amino acids, asparagine and glutamine, are two of the twenty amino acids used in translation by all known life. The aminoacyl-tRNA synthetases for asparagine and glutamine, asparaginyl-tRNA synthetase and glutaminyl tRNA synthetase, evolved after the split in the last universal common ancestor of modern organisms. Before that split, life used two-step indirect pathways to synthesize asparagine and glutamine on their cognate tRNAs to form the aminoacyl-tRNA used in translation. These two-step pathways were retained throughout much of the bacterial and archaeal domains of life and eukaryotic organelles. The indirect routes use non-discriminating aminoacyl-tRNA synthetases (non-discriminating aspartyl-tRNA synthetase and non-discriminating glutamyl-tRNA synthetase) to misaminoacylate the tRNA. The misaminoacylated tRNA formed is then transamidated into the amide aminoacyl-tRNA used in protein synthesis by tRNA-dependent amidotransferases (GatCAB and GatDE). The enzymes and tRNAs involved assemble into complexes known as transamidosomes to help maintain translational fidelity. These pathways have evolved to meet the varied cellular needs across a diverse set of organisms, leading to significant variation. In certain bacteria, the indirect pathways may provide a means to adapt to cellular stress by reducing the fidelity of protein synthesis. The retention of these indirect pathways versus acquisition of asparaginyl-tRNA synthetase and glutaminyl tRNA synthetase in lineages likely involves a complex interplay of the competing uses of glutamine and asparagine beyond translation, energetic costs, co-evolution between enzymes and tRNA, and involvement in stress response that await further investigation.

Nano-therapeutics: The upcoming nanomedicine to treat cancer

Khan H, Shahab U, Alshammari A, Alyahyawi AR, Akasha R, Alharazi T, et al. IUBMB Life. 2024; 76(8): 468-484.

Nanotechnology is considered a successful approach for cancer diagnosis and treatment. Preferentially, cancer cell recognition and drug targeting via nano-delivery system include the penetration of anticancer agents into the cell membrane to damage the cancer cell by protein modification, DNA oxidation, or mitochondrial dysfunction. The past research on nano-delivery systems and their target has proven the beneficial achievement in a malignant tumor. This review focuses on using a nano-delivery system, an imaging system, and encapsulated nanoparticles for cancer therapy.

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SPECIAL ISSUES OPEN FOR SUBMISSION

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

  • A short title that can clearly describe the scope of special issue;
  • A short introduction about the significance of the special issue;
  • Basic information and CV of Lead Guest Editor and Co-Guest Editors;
  • List of potential authors and their tentative article titles;
  • The estimated number of submissions;
  • Proposed timeline.

Please visit the journal homepage for more information.

BioFactors
New Issue: Volume 50, Issue 4

Issue Highlights (Open Access)

Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer’s disease

Abdul-Rahman T, Awuah WA, Mikhailova T, Kalmanovich J, Mehta A, Ng JC, et al. BioFactors. 2024; 50(4): 693-708.

Alzheimer’s disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological interventions have shown limited efficacy and are associated with significant side effects. Approaches focusing on the early interference with disease pathways, before activation of broad neurotoxic processes, could be promising to slow down symptomatic progression of the disease. Curcumin—an integral component of traditional medicine in numerous cultures worldwide— has garnered interest as a promising AD treatment. This article aims to raise awareness of the neuroprotective properties of curcuminoids that could provide therapeutic benefits in AD. The paper provides a comprehensive overview of the neuroprotective efficacy of curcumin against signaling pathways that could be involved in AD and summarizes recent evidence of the biological efficiency of curcumins in vivo.

Sulforaphane prevents diabetes-induced hepatic ferroptosis by activating Nrf2 signaling axis

Savic N, Markelic M, Stancic A, Velickovic K, Grigorov I, Vucetic M, et al. BioFactors. 2024; 50(4): 810–827.

Recently, the authors have characterized the ferroptotic phenotype in the liver of diabetic mice and revealed nuclear factor (erythroid-derived-2)-related factor 2 (Nrf2) inactivation as an integral part of hepatic injury. Here, the authors aim to investigate whether sulforaphane, an Nrf2 activator and antioxidant, prevents diabetes-induced hepatic ferroptosis and the mechanisms involved.

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CALL FOR PAPERS

Uncovering biomarkers in the tumor-immune microenvironment and analyzing their potential regulatory mechanisms

Topics for this call for papers include but are not restricted to:

  • Identification and validation of biomarkers for cancer diagnosis, prognosis, and treatment personalization
  • Novel biomarkers of immunotherapy response or resistance
  • Advances in technologies for profiling tumor-immune interactions
  • The application of genomics and other omics technologies in understanding the heterogeneity of solid tumors
  • Therapeutic strategies targeting the immune system in cancer

Submission deadline: Sunday, 30 March 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

  • A short title that can clearly describe the scope of special issue.
  • A short introduction about the significance of the special issue.
  • Basic information and CV of Lead Guest Editor and Co-Guest Editors.
  • List of potential authors and their tentative article titles.
  • The estimated number of submissions.
  • Proposed timeline.

Please visit the journal homepage for more information.

Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 4

Issue Highlights (Open Access)

Accumulation and toxicity of biologically produced gold nanoparticles in different types of specialized mammalian cells

Pourali P, Svoboda M, Neuhöferová E, Dzmitruk V, Benson V. Biotechnol Appl Biochem. 2024; 71: 766-778.

In summary, the authors proved the biologically produced AuNPs entered all the tested cell types and triggered cell-specific responses. High AuNP uptake by tumor cells was related to decreased cell viability, while low nanoparticle uptake by fibroblasts triggered F-actin reorganization without remarkable toxicity. Thus, the biologically produced AuNPs hold promising potential as cancer drug carriers and likely require proper surface functionalization to shield phagocytizing cells.

The effects of hyaluronan and proteoglycan link protein 1 (HAPLN1) in ameliorating spinal cord injury mediated by Nrf2

Yang H, Hu B, Wang X, Chen W, Zhou H. Biotechnol Appl Biochem. 2024; 71: 929–939.

Excessive inflammatory response and oxidative stress (OS) play an important role in the pathogenesis of spinal cord injury (SCI). Balance of inflammation and prevention of OS have been considered an effective strategy for the treatment of SCI. Hyaluronan and proteoglycan link protein 1 (HAPLN1), also known as cartilage link protein, has displayed a wide range of biological and physiological functions in different types of tissues and cells. However, whether HAPLN1 regulates inflammation and OS during SCI is unknown. Therefore, the authors aimed to examine whether HAPLN1 can have a protective effect on SCI. In this study, both in vitro and in vivo SCI models were established.

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CALL FOR PAPERS

Leveraging Genomics Data in Blockchain for Medical Research Ethics

The Special Issue aims to create a dialogue on leveraging genomics data in blockchain for medical research ethics. Also, we plan to attract researchers with a diverse range of studies that explore theoretical frameworks, technological innovations, policy analyses, and case studies demonstrating practical applications and challenges.

Topics for this call for papers include but are not restricted to:

  • Ethical frameworks for genomic data ownership and sharing on blockchain platforms;
  • Technological advancements in secure and scalable blockchain systems for genomic data;
  • Interoperability challenges and solutions in integrating genomics with different blockchain architectures;
  • Regulatory landscape and policy recommendations for blockchain in genomics;
  • Economic models for incentivizing the sharing of genomic data on blockchain platforms;
  • Impact assessments of blockchain on the speed and efficacy of medical research;
  • Legal implications of decentralized genomic data management;
  • Ethical considerations in the use of smart contracts for genomic data consent management;
  • Comparative analyses of global initiatives employing blockchain for genomics;
  • Challenges and strategies for educating stakeholders about the benefits and risks of blockchain in genomics;
  • Future prospects of integrating artificial intelligence with blockchain and genomics for advanced medical research;
  • Privacy-preserving techniques for genomic data on blockchain: challenges and future directions;
  • Case studies of blockchain applications in enhancing privacy and consent in genomics research.

Deadline for Submissions: 1 December 2024

Guest Editors: Dr Muzammil Hussain (Lead), Pakistan; Dr Muhammad Adnan Khan, Gachon University, The Republic of Korea; Dr Kiran Adnan, Malaysia

—

Searching for a New Editor-in-Chief for Biotechnology and Applied Biochemistry

The International Union of Biochemistry and Molecular Biology (IUBMB) seeks a new Editor-in-Chief for Biotechnology and Applied Biochemistry. Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of discoveries in the life sciences that impact and advance biotechnology. The Editor will consider papers for publication based on their potential impact on the field, and their compatibility with journal scope. The journal seeks contributions to the fields of synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology, and how they can be applied to medical and industrial biotechnology.

The successful candidate will be recognized as a leading member of the biochemistry and molecular biology community. They will have an outstanding publication record; an extensive, global network; an appreciation for the diverse fields within the journal’s scope; and will represent the diversity within the IUBMB global community.

The successful candidate will have an outstanding opportunity to further develop the journal over a maximum three 3-year terms in the role commencing July 1, 2025. They must demonstrate a clear vision for its future growth and position in the publishing landscape. The appointee will bring extensive experience in peer review and/or editorial roles, high ethical professional standards, innovation, enthusiasm, strong leadership, and organizational and communication skills to the journal.

The main functions within this role are: strategic and practical development of the journal, defining a vision for the content; defining content and commissioning papers for regular and special issues; maintaining editorial standards; providing strong and inspiring leadership to the journal’s editorial board; appointing new board members to grow the journal; promoting the journal; managing the publication, and working closely with IUBMB and the publisher (Wiley). This important leadership role will require a significant time commitment on a weekly basis and will be recompensed accordingly. Associate Editors are appointed to limited terms by the Editors-in-Chief to handle some functions, subject to approval by the IUBMB Executive Committee. The Editor-in-Chief of Biotechnology and Applied Biochemistry will receive an annual honorarium and is supported by professional editorial office assistance.

Applications should include the following

  1. A full CV, including details of peer review and/or editorial roles and the applicant’s publication record
  2. A brief statement describing your vision for Biotechnology and Applied Biochemistry
  3. A cover letter outlining your suitability for the Editor-in-Chief role
  4. Two reference Letters

Please send any queries relating to this appointment and applications, in confidence, to: Prof. James Murphy (jamesm@wehi.edu.au), Chair of the IUBMB Publications Committee. Application deadline October 31, 2024.

Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 4

bmb.21750.fp

Issue Highlights (Open Access)

Exploring in the classroom the relationship between alcohol intake and behavioral disorders through an animal model

Hernández-García S, Guerrero-Rubio MA, Henarejos-Escudero P, Martínez-Rodríguez P, Gandía- Herrero F. Biochem Mol Biol Educ. 2024; 52(4): 474–479.

Alcohol consumption has profound effects on behavior, such as impaired judgment, addiction or even death. It is estimated that alcohol contributes to around three million deaths worldwide, 13.5% of them in young people with ages between 20 and 39 years. Consequently, it is necessary to raise awareness among college and high school students of the risk related to alcohol drinking. The small nematode Caenorhabditis elegans is an animal widely used as a model organism to study nearly all aspects of Biochemistry. It is a powerful tool to test the potential bioactivity and molecular mechanisms of natural compounds and drugs in vivo. Therefore, it is an interesting topic to include in an undergraduate course of Biotechnology, Biochemistry or Biology students among other scientific vocations.

If you are learner-centered and you know it, raise your hand: Perspectives on and implementation of pedagogical changes by science instructors during the COVID-19 pandemic

Donham C, Hong H, Signorini A, Menke E, Kranzfelder P. Biochem Mol Biol Educ. 2024; 52(4): 386-402.

Students at Minority-Serving Institutions (MSIs) faced significant hardships while trying to learn through emergency remote teaching (ERT) during the COVID-19 pandemic. This research aims to investigate if science, technology, engineering, and mathematics (STEM) instructors thought about and enacted more learner-centered teaching practices to alleviate some of this stress encountered by their students. Using semi-structured interviews and classroom observations, the authors utilized inductive and deductive qualitative research methods to examine two questions: (1) To what extent were STEM instructor’s perceived pedagogical changes learner-centered during ERT?; and (2) To what extent were STEM instructor’s teaching behaviors and discourse practices learner-centered during ERT?

Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

Elsevier logo

Molecular Aspects of Medicine

Molecular Aspects of Medicine

Volume 97 (June 2024) 101273
Obesity and male fertility disorders

Rossella Cannarella, Andrea Crafa, Roberto Curto, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero

Volume 97 (June 2024) 101271
Biomarkers of frailty

Mariam El Assar, Isabel Rodríguez-Sánchez, Alejandro Álvarez-Bustos, Leocadio Rodríguez-Mañas

Aspects of Molecular Medicine

Aspects of Molecular Medicine LOW RES for overprint placement

Volume 4 (December 2024) 100052
Patient-related factors drive high rates of reported antibiotic allergies: A qualitative study

Renee Berry, Susan Herrmann, Michaela Lucas

Volume 4 (December 2024) 100046

Genome-wide linkage and association of novel genes and pathways with type 2 diabetes in Italian families

Mutaz Amin, Claudia Gragnoli

IUBMB Journals

IUBMB Journal Highlights | July 2024

Posted on | by Charysse Austria
IUBMB Journals
Wiley Logo

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!
• Disease causing gene mutations
• Human Genetic Disorders
• Therapeutic strategies targeting disease-associated mutations

IUBMB Life
New Issue: Volume 76, Issue 7

iub2748-gra-0001-m

Issue Highlights

Matrix-based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma

Mastronikolis NS, Kyrodimos E, Piperigkou Z, Spyropoulou D, Delides A, Giotakis E, et al. IUBMB Life. 2024; 76(7): 368–382.

Oral squamous cell carcinoma (OSCC), a type of head and neck cancer (HNC), is known for its high mortality rate and potential for regional and distant metastasis. Recent advancements in research have enhanced our understanding of the molecular mechanisms driving OSCC metastasis. The extracellular matrix (ECM) plays a crucial role in this process, influencing cellular morphology, function, transcription, and signaling mechanisms involved in invasion and metastasis. This review critically examines recent research on the involvement of ECM components, such as proteoglycans, integrins, and matrix metalloproteinases, in the development and progression of OSCC.

Schizosaccharomyces pombe as a fundamental model for research on mitochondrial gene expression: Progress, achievements and outlooks

Dinh N, Bonnefoy N. IUBMB Life. 2024; 76(7): 397-419.

Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial research. The organism resembles human cells in terms of mitochondrial inheritance, mitochondrial transport, sugar metabolism, mitogenome structure and dependence of viability on the mitogenome (the petite-negative phenotype). Here, the authors review the current state of knowledge regarding S. pombe mitochondrial gene expression, and emphasise the pertinence of fission yeast as both a model and tool, especially for studies on mitochondrial translation.
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CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

  • A short title that can clearly describe the scope of special issue;
  • A short introduction about the significance of the special issue;
  • Basic information and CV of Lead Guest Editor and Co-Guest Editors;
  • List of potential authors and their tentative article titles;
  • The estimated number of submissions;
  • Proposed timeline.

Please visit the journal homepage for more information.

BioFactors
New Issue: Volume 50, Issue 3

biof.v50.3.cover

Issue Highlights (Open Access)

A glimpse into the structural properties of α-synuclein oligomers

Santos J, Pallarès I, Ventura S. BioFactors. 2024; 50(3): 439-449.

α-Synuclein (αS) aggregation is the main neurological hallmark of a group of debilitating neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson’s disease is the most prevalent. αS oligomers formed during the initial stages of aggregation are considered key pathogenic drivers of disease onset and progression, standing as privileged targets for therapeutic intervention and diagnosis. In this review, the authors delve into the recent advances in the structural and mechanistic characterization of αS oligomers, and discuss how these advances are transforming our understanding of these elusive species and paving the way for oligomer-targeting therapeutics and diagnosis.

Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration

Diomede F, Guarnieri S, Lanuti P, Konstantinidou F, Gatta V, Rajan TS, et al. BioFactors. 2024; 50(3): 509–522.

Mesenchymal stem cells (MSCs) are promising for treating heart and vascular diseases, with the potential to differentiate into cardiomyocytes. This study focuses on using extracellular vesicles (EVs) from human dental pulp stem cells (hDPSCs) as a safer and cost-effective alternative to MSCs. The EVs were found to influence cardiomyogenic differentiation by up-regulating key genes like GATA4, ACTC1, CX43, and Nkx2.5. A significant down-regulation of microRNA hsa-miR-200c-3p, which targets GATA4, suggests an epigenetic mechanism at play. The research aims to establish an in vitro model of hDPSCs differentiating into cardiomyocytes, highlighting the potential of EVs from hDPSCs and the HL-1 cell line in this process.

—

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

  • A short title that can clearly describe the scope of special issue.
  • A short introduction about the significance of the special issue.
  • Basic information and CV of Lead Guest Editor and Co-Guest Editors.
  • List of potential authors and their tentative article titles.
  • The estimated number of submissions.
  • Proposed timeline.

Please visit the journal homepage for more information.

Congratulations to the winners!

We are pleased to announce the winners of the 2023 Wiley-BioFactors Young Investigator Award!

Congratulation to award winner Patricia Recio-López for the article Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII on the efficiency of i.v. administration in silico designed siRNAs to selectively and specifically silence mouse liver derived apoCIII with a higher potency and longer duration than previously tested ASO.

Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 3

bab.2477.fp_cover

Issue Highlights

Innovations in dengue virus detection: An overview of conventional and electrochemical biosensor approaches

Raza S, Poria R, Kala D, Sharma N, Sharma AK, Florien N, et al.  Biotechnol Appl Biochem. 2024; 71: 481-500.

Globally, people are in great threat due to the highly spreading of viral infectious diseases. Every year like 100–300 million cases of infections are found, and among them, above 80% are not recognized and irrelevant. Dengue virus (DENV) is an arbovirus infection that currently infects people most frequently. DENV encompasses four viral serotypes, and they each express comparable sign. From a mild febrile sickness to a potentially fatal dengue hemorrhagic fever, dengue can induce a variety of symptoms.

Presently, the globe is being challenged by the untimely identification of dengue infection. Therefore, this review summarizes advances in the detection of dengue from conventional methods (nucleic acid-based, polymerase chain reaction-based, and serological approaches) to novel biosensors. This work illustrates an extensive study of the current designs and fabrication approaches involved in the formation of electrochemical biosensors for untimely identifications of dengue.

Study of selenium enrichment metabolomics in Bacillus subtilis BSN313 via transcriptome analysis

Ullah A, Yin X, Naveed M, Aslam S, Chan MWH, Bo S, et al. Biotechnol Appl Biochem. 2024; 71: 609–626.

In this study, the transcriptome analysis was practiced to identify potential genes of probiotic Bacillus subtilis BSN313 involved in selenium (Se) enrichment metabolism, and it was concluded that SeMet was the highest content of organic Se byproduct biosynthesized by B. subtilis BSN313 strain in Se-enriched medium during stationary phase. Thus, B. subtilis BSN313 can be considered a commercial probiotic strain that can be used in the food and pharmaceutical industries. This is because it can meet the commercial demand for Se-AAs (SeMet) in both industries

—

CALL FOR PAPERS

Leveraging Genomics Data in Blockchain for Medical Research Ethics

The Special Issue aims to create a dialogue on leveraging genomics data in blockchain for medical research ethics. Also, we plan to attract researchers with a diverse range of studies that explore theoretical frameworks, technological innovations, policy analyses, and case studies demonstrating practical applications and challenges.

Topics for this call for papers include but are not restricted to:

  • Ethical frameworks for genomic data ownership and sharing on blockchain platforms;
  • Technological advancements in secure and scalable blockchain systems for genomic data;
  • Interoperability challenges and solutions in integrating genomics with different blockchain architectures;
  • Regulatory landscape and policy recommendations for blockchain in genomics;
  • Economic models for incentivizing the sharing of genomic data on blockchain platforms;
  • Impact assessments of blockchain on the speed and efficacy of medical research;
  • Legal implications of decentralized genomic data management;
  • Ethical considerations in the use of smart contracts for genomic data consent management;
  • Comparative analyses of global initiatives employing blockchain for genomics;
  • Challenges and strategies for educating stakeholders about the benefits and risks of blockchain in genomics;
  • Future prospects of integrating artificial intelligence with blockchain and genomics for advanced medical research;
  • Privacy-preserving techniques for genomic data on blockchain: challenges and future directions;
  • Case studies of blockchain applications in enhancing privacy and consent in genomics research.

Deadline for Submissions: 1 December 2024

Guest Editors: Dr Muzammil Hussain (Lead), Pakistan; Dr Muhammad Adnan Khan, Gachon University, The Republic of Korea; Dr Kiran Adnan, Malaysia

—

Searching for a New Editor-in-Chief for Biotechnology and Applied Biochemistry

The International Union of Biochemistry and Molecular Biology (IUBMB) seeks a new Editor-in-Chief for Biotechnology and Applied Biochemistry. Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of discoveries in the life sciences that impact and advance biotechnology. The Editor will consider papers for publication based on their potential impact on the field, and their compatibility with journal scope. The journal seeks contributions to the fields of synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology, and how they can be applied to medical and industrial biotechnology.

The successful candidate will be recognized as a leading member of the biochemistry and molecular biology community. They will have an outstanding publication record; an extensive, global network; an appreciation for the diverse fields within the journal’s scope; and will represent the diversity within the IUBMB global community.

The successful candidate will have an outstanding opportunity to further develop the journal over a maximum three 3-year terms in the role commencing July 1, 2025. They must demonstrate a clear vision for its future growth and position in the publishing landscape. The appointee will bring extensive experience in peer review and/or editorial roles, high ethical professional standards, innovation, enthusiasm, strong leadership, and organizational and communication skills to the journal.

The main functions within this role are: strategic and practical development of the journal, defining a vision for the content; defining content and commissioning papers for regular and special issues; maintaining editorial standards; providing strong and inspiring leadership to the journal’s editorial board; appointing new board members to grow the journal; promoting the journal; managing the publication, and working closely with IUBMB and the publisher (Wiley). This important leadership role will require a significant time commitment on a weekly basis and will be recompensed accordingly. Associate Editors are appointed to limited terms by the Editors-in-Chief to handle some functions, subject to approval by the IUBMB Executive Committee. The Editor-in-Chief of Biotechnology and Applied Biochemistry will receive an annual honorarium and is supported by professional editorial office assistance.

Applications should include the following

  1. A full CV, including details of peer review and/or editorial roles and the applicant’s publication record
  2. A brief statement describing your vision for Biotechnology and Applied Biochemistry
  3. A cover letter outlining your suitability for the Editor-in-Chief role
  4. Two reference Letters

Please send any queries relating to this appointment and applications, in confidence, to: Prof. James Murphy (jamesm@wehi.edu.au), Chair of the IUBMB Publications Committee. Application deadline October 31, 2024.

Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 4

bmb.21750.fp

Issue Highlights (Open Access)

Detection and enzymatic characterization of human saliva amylase

Vey CT, Kaygusuz V, Kayser JS, Beyer A. Biochem Mol Biol Educ. 2024; 52(4): 379–385.

As a rule, an experiment carried out at school or in undergraduate study courses is rather simple and not very informative. However, when the experiments are to be performed using modern methods, they are often abstract and difficult to understand. Here, the authors describe a quick and simple experiment, namely the enzymatic characterization of ptyalin (human salivary amylase) using a starch degradation assay. With the experimental setup presented here, enzyme parameters, such as pH optimum, temperature optimum, chloride dependence, and sensitivity to certain chemicals can be easily determined. This experiment can serve as a good model for enzyme characterization in general, as modern methods usually follow the same principle: determination of the activity of the enzyme under different conditions. As different alleles occur in humans, a random selection of test subjects will be quite different with regard to ptyalin activities. Therefore, when the students measure their own ptyalin activity, significant differences will emerge, and this will give them an idea of the genetic diversity in human populations. The evaluation has shown that the pupils have gained a solid understanding of the topic through this experiment.

Use of OneNote class notebook as a combined electronic laboratory notebook and content delivery tool in an introductory biochemistry laboratory course

Khan-Trottier A. Biochem Mol Biol Educ. 2024; 52(4): 462-473.

α-Synuclein (αS) aggregation is the main neurological hallmark of a group of debilitating neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson’s disease is the most prevalent. αS oligomers formed during the initial stages of aggregation are considered key pathogenic drivers of disease onset and progression, standing as privileged targets for therapeutic intervention and diagnosis. In this review, the authors delve into the recent advances in the structural and mechanistic characterization of αS oligomers, and discuss how these advances are transforming our understanding of these elusive species and paving the way for oligomer-targeting therapeutics and diagnosis.

Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

Elsevier logo

Molecular Aspects of Medicine

Molecular Aspects of Medicine

Volume 99 (October 2024) 101303
Diabetes and male fertility disorders

Andrea Graziani, Raffaele Scafa, Giuseppe Grande, Alberto Ferlin

Volume 99 (October 2024) 101293
Molecular mechanisms of cancer cachexia. Role of exercise training

Eva Tamayo-Torres, Amanda Garrido, Rafael de Cabo, Julián Carretero, María Carmen Gómez-Cabrera

Aspects of Molecular Medicine

Aspects of Molecular Medicine LOW RES for overprint placement

Volume 4 (December 2024) 100048
Plants as a source of dietary bioactives: Flavonoids and basis for their health benefits

Andrea Galatro , Agustin Lucini Mas, Melisa Luquet, Cesar G. Fraga, Monica Galleano

Volume 3 (June 2024) 100033
Human serum albumin binds spike protein and protects cells from SARS-CoV-2 infection by modulating the RAS pathway

Romualdo Varricchio , Giovanna De Simone  Gian Marco Vita, Walter Nocera Cariola, Maurizio Viscardi, Sergio Brandi, Gerardo Picazio, Verena Zerbato, Raffaella Koncan, Ludovica Segat, Stefano Di Bella, Giovanna Fusco, Paolo Ascenzi, Alessandra di Masi

Congratulations to our IUBMB Fellows of April 2024

Posted on | by Charysse Austria

CONGRATULATIONS to our latest Wood Whelan Fellows from Argentina, Cuba, and South Africa, who have received fellowships to travel to a lab in a different country for 4 months. We wish them much success in their research!

2024 April_WW Fellowship_Twitter
 
2024 April_WW Fellowship_Twitter
2024 April_WW Fellowship_Delfina Gagliardi_Twitter
 
2024 April_WW Fellowship_Delfina Gagliardi_Twitter
2024 April_WW Fellowship_Beatriz Millares_Twitter
 
2024 April_WW Fellowship_Beatriz Millares_Twitter
2024 April_WW Fellowship_Tosin Olasehinde_Twitter
 
2024 April_WW Fellowship_Tosin Olasehinde_Twitter
2024 April_WW Fellowship_Ana Ortiz_Twitter
 
2024 April_WW Fellowship_Ana Ortiz_Twitter
2024 April_WW Fellowship_Maria Emilia Roulet_Twitter
 
2024 April_WW Fellowship_Maria Emilia Roulet_Twitter

Congratulations to the 2024 PROBio-Africa Fellows

Posted on | by Charysse Austria

Congratulations to the winners of the PROBio-Africa Fellowships Program, the funding collaboration between IUBMB, FEBS, and FASBMB.

We wish all the fellows a great laboratory stay and the best in their future careers!

2024 PROBio-Africa_All
 
2024 PROBio-Africa_All
2024 PROBio-Africa_Emeka Godwin Anaduaka
 
2024 PROBio-Africa_Emeka Godwin Anaduaka
2024 PROBio-Africa_Ifeoma Felicia Chukwuma
 
2024 PROBio-Africa_Ifeoma Felicia Chukwuma
2024 PROBio-Africa_Tobechkwu Christian Ezike
 
2024 PROBio-Africa_Tobechkwu Christian Ezike
2024 PROBio-Africa_Mary George
 
2024 PROBio-Africa_Mary George
2024 PROBio-Africa_John Onyebuchi Ogbodo
 
2024 PROBio-Africa_John Onyebuchi Ogbodo
2024 PROBio-Africa_Nada Zaari Jabri
 
2024 PROBio-Africa_Nada Zaari Jabri

FEBS-IUBMB-ENABLE 2nd International Molecular Biosciences PhD and Postdoc Conference, 23–25 November 2023, University of Cologne, Germany

Posted on | by Charysse Austria

FEBS Open Bio - 2024 - - Front Cover

 
The FEBS Open Bio supplement of June 2024 contains the report on the FEBS-IUBMB-ENABLE 2nd International Molecular Biosciences PhD and Postdoc Conference, The emerging challenge, Environmental impacts on human health, 23–25 November 2023, University of Cologne, Germany.

2023 Conference Report >   |   Abstract book >

IUBMB Journals

IUBMB Journal Highlights | May 2024

Posted on | by Charysse Austria
IUBMB Journals
Wiley Logo

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!
• Disease causing gene mutations
• Human Genetic Disorders
• Therapeutic strategies targeting disease-associated mutations

IUBMB Life
New Issue: Volume 76, Issue 5

iub.v76.5.cover

Issue Highlights

Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells

Khasawneh RR, Abu-El-Rub E, Almahasneh FA, Alzu’bi A, Zegallai HM, Almazari RA, et al. IUBMB Life. 2024; 76(5): 286–295.

Mesenchymal stem cells (MSCs) are a therapeutically efficient type of stem cells validated by their ability to treat many inflammatory and chronic conditions. The biological and therapeutic characteristics of MSCs can be modified depending on the type of microenvironment at the site of transplantation. Diabetes mellitus (DM) is a commonly diagnosed metabolic disease characterized by hyperglycemia, which alters over time the cellular and molecular functions of many cells and causes their damage. Hyperglycemia can also impact the success rate of MSCs transplantation; therefore, it is extremely significant to investigate the effect of high glucose on the biological and therapeutic attributes of MSCs, particularly their immunomodulatory abilities. In this study, the authors explored the effect of high glucose on the immunosuppressive characteristics of human adipose tissue-derived mesenchymal stem cells (hAD-MSCs).

CALL FOR PAPERS – SPECIAL ISSUE

  1. Special Issue on from DNA to protein: molecular mechanisms and tailored approaches to correct genetic defects associated with human disorders

    The special issue objective is to collect research manuscripts or review articles, providing new or summarizing available experimental evidence in cellular and/or in vivo models of disease on the identification and characterization of disease-causing molecular approaches. As well as approaches designed to correct gene mutations at different levels.

    Topics for this call for papers include but not restricted to:
    • Disease causing gene mutations
    • Human Genetic Disorders
    • Therapeutic strategies targeting disease-associated mutations

    Guest Editor: Alessio Branchini, University of Ferrara, Ferrara, Italy
    Deadline for Submissions: 31 October 2024

  2. Special Issue on Environmental Management and Biomedical Research

    This special issue aims to facilitate the dissemination of cutting-edge scientific research that explores microbial-driven waste remediation strategies, delves into microbial community dynamics in waste environments, and investigates the potential of microbial systems in medical breakthroughs.

    Topics for this call for papers include but not restricted to:
    • Microbial-driven waste degradation mechanisms
    • Innovations in waste bioremediation techniques
    • Microbial interactions in diverse waste environments

    Guest Editor: Alessio Branchini, University of Ferrara, Ferrara, Italy
    Deadline for Submissions: 10 September 2024

WELCOME NEW ASSOCIATE EDITORS AND EDITORIAL BOARD MEMBERS!

New Associate Editors
Alexander Bürkle – University of Konstanz, Konstanz, Germany
Flavia Fontanesi – University of Miami, Miami, USA
Nesrin Kartal Ozer – Uskudar University, Istanbul, Turkiye

New Editorial Board Editors
Alexandra Newton – University of California San Diego, USA
Dario Alessi – University of Dundee, UK
Iqbal Parker – University of Cape Town, South Africa
Loredano Pollegioni – University of Insubria, Varese, Italy
Ilona Concha Grabinger – Universidad Austral de Chile, Chile
Lim Yang Mooi – Universiti Tunku Abdul Rahman, Malaysia
James Murphy – Walter and Eliza Hall Institute of Medical Research, Australia
Alessio Branchini – University of Ferrara, Italy

BioFactors
New Issue: Volume 50, Issue 2

BioFactors - 2024 - - Issue Information ‐ Cover _April

Issue Highlights (Open Access)

BAG3 regulates cilia homeostasis of glioblastoma via its WW domain

Roth C, Paulini L, Hoffmann ME, Mosler T, Dikic I, Brunschweiger A, et al. BioFactors. 2024

The authors compared BAG3 protein–protein interactions in either adherently cultured or stem-like cultured U251 GBM cells, and in line with BAG3’s putative role in regulating stem-like properties, identified interactors in sphere-cultured cells included different stem cell markers (SOX2, OLIG2, and NES), while interactomes of adherent BAG3-proficient cells indicated a shift toward involvement of BAG3 in regulation of cilium assembly (ACTR3 and ARL3).

Insights into the antiosteoporotic mechanism of the soy-derived isoflavone genistein: Modulation of the Wnt/beta-catenin signaling

Mannino F, Imbesi C, Irrera N, Pallio G, Squadrito F, Bitto A. BioFactors. 2024; 50(2): 347-359

The aim of this study was to investigate whether estrogen receptor stimulation by genistein might promote osteoblast and osteocyte function during glucocorticoid challenge.

Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 2

BAB 71.2

Issue Highlights

Analysis of highly frequent point mutations in glycoprotein C, glycoprotein N, and nucleoprotein of CCHFV

Kaushal N, Baranwal M. Biotechnol Appl Biochem. 2024; 71: 280–294

Crimean-Congo hemorrhagic fever virus (CCHFV) is classified among the top 10 priority pathogens by World Health Organization. CCHFV belongs to Bunyaviridae family and negative sense ssRNA genome composed of three RNA segments: L, M, and S. RNA viruses show higher mutation rate as compared to DNA viruses. This study is focused on evaluating eight mutations in structural glycoproteins (Gc: 7 and Gn: 1) of M segment and seven mutations in NP of S segment.

Improving the capturing ability of swirl-based microfluidic chip by introducing baffle wall

Dang Y, Zhang Q, Ou Z, Hu S. Biotechnol Appl Biochem. 2024; 71: 336-355

Microfluidics technology is promising in developing microparticle manipulation technology due to its nondestructive control and notable adaptability. The manipulation of microparticle based on swirling stagnation point is one of the feasible microfluidics biotechnologies. Aiming to improve the regulation and control of microparticle, baffle wall is introduced into the 2-microchannel flow field.

FTO-mediated ZNF687 accelerates tumor growth, metastasis, and angiogenesis in colorectal cancer through the Wnt/β-catenin pathway

Li J, Li S, Xing X, Liu N, Lai S, Liao D, et al. Biotechnol Appl Biochem. 2024; 71: 245-255

Colorectal cancer (CRC) is a common and lethal cancer. ZNF687 has been disclosed to take part in diversified cancers’ progression by serving as a facilitator. However, the detailed regulatory functions of ZNF687 in the CRC have not been investigated. This work is planned to probe the impacts of ZNF687 on CRC progression.

Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 2

BAMBed - 2024_Vol 52.2_Page_1

Issue Highlights (Open Access)

When online citizen science meets teaching: Storyfication of a science discovery game to teach, learn, and contribute to genomic research

Drogaris C, Butyaev A, Nazarova E, Sarrazin-Gendron R, Patel H, Singh A, et al. Biochem Mol Biol Educ. 2024; 52(2): 145–155

In the last decade, video games became a common vehicle for citizen science initiatives in life science, allowing participants to contribute to real scientific data analysis while learning about it. Since 2010, the authors scientific discovery game (SDG) Phylo enlists participants in comparative genomic data analysis. It is frequently used as a learning tool, but the activities were difficult to aggregate to build a coherent teaching activity. Here, they describe a strategy and series of recipes to facilitate the integration of SDGs in courses and implement this approach in Phylo.

Embedding retrieval practice in undergraduate biochemistry teaching using PeerWise

Higgins T, Dudley E, Bodger O, Newton P, Francis N. Biochem Mol Biol Educ. 2024; 52(2): 156–164

Retrieval practice is an evidence-based approach to teaching; here, the authors evaluate the use of PeerWise for embedding retrieval practice into summative assessment.

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Welcome New Editor-in-Chief!

University of Michigan-Dearborn MI, USA

Professor Marilee Benore, a STEM advocate, holds a PhD in chemistry from the University of Delaware. She’s a teacher-scholar, researching vitamin transport and biochemistry education at the University of Michigan-Dearborn. As an active member of the education community, she has served on numerous committees of the American Society of Biochemistry and Molecular Biology (ASBMB). Her commitment to diversity and inclusion earned her awards, including ASBMB Fellow in 2023.

Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

Elsevier logo

Molecular Aspects of Medicine

Molecular Aspects of Medicine

Volume 93 (October 2023) 101204

Advances in vaccine development for cancer prevention and treatment in Lynch Syndrome

Ana M. Bolivar, Fahriye Duzagac, Krishna M. Sinha, Eduardo Vilar

Aspects of Molecular Medicine

Aspects of Molecular Medicine LOW RES for overprint placement

Volume 3 (June 2024) 100033

Human serum albumin binds spike protein and protects cells from SARS-CoV-2 infection by modulating the RAS pathway

Romualdo Varricchio a 1, Giovanna De Simone a1, Gian Marco Vita a, Walter Nocera Cariola a, Maurizio Viscardi b, Sergio Brandi b, Gerardo Picazio b, Verena Zerbato c, Raffaella Koncan d e, Ludovica Segat d, Stefano Di Bella e, Giovanna Fusco b, Paolo Ascenzi a, Alessandra di Masi a

Congratulations to our IUBMB Fellows of October 2023

Posted on | by Charysse Austria


CONGRATULATIONS to our latest Wood Whelan Fellows from Argentina, Australia, Pakistan, and Ukraine, who have received fellowships to travel to a lab in a different country for 4 months. We wish them much success in their research!

 
 
 
 
 
 
Oct 2023 Fellowships_Monica Bequet_Twitter