Author: Charysse Austria

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!

IUBMB Life
New Issue: Volume 77, Issue 3

The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells

Li Y, Jiang X, Cao H, Wu X, Zhang H, Ma H, et al. The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells. IUBMB Life. 2025; 77(3):e70009.

The cGAS-STING signaling pathway plays a key role in the immune response against colorectal adenocarcinoma (COAD). This study explores its impact on COAD prognosis by analyzing gene mutations, copy number variations, DNA methylation, and gene expression using multi-omics data from TCGA and GEO databases. Key genes, including CASP8 and RIPK1, were assessed for their prognostic significance, and core genes—NLRC3, CASP1, AIM2, and CXCL10—were validated through tissue analysis. A prognostic model linking these genes to poor tumor outcomes via immune cell infiltration was developed, offering insights for cancer immunotherapy and precision medicine.

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SPECIAL ISSUES OPEN FOR SUBMISSION

• Special Issue on Computational Biology in Identification of Potential Biomarkers for Cancer Immunotherapy
  • Deadline for Submissions: 31 July 2025

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue;
• A short introduction about the significance of the special issue;
• Basic information and CV of Lead Guest Editor and Co-Guest Editors;
• List of potential authors and their tentative article titles;
• The estimated number of submissions;
• Proposed timeline.

Please visit the journal homepage for more information.

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BioFactors
New Issue: Volume 51, Issue 2

Spatial and single-cell transcriptomic analysis reveals fibroblasts dependent immune environment in colorectal cancer

Jia H, Liu X, Wang G, Yu Y, Wang N, Zhang T, et al. Spatial and single-cell transcriptomic analysis reveals fibroblasts dependent immune environment in colorectal cancer. BioFactors. 2025; 51(2):e70012

Colorectal cancer (CRC) has a complex tumor microenvironment influenced by cancer-associated fibroblasts. This study used single-cell RNA sequencing and spatial transcriptomics to analyze fibroblast heterogeneity in CRC. Key genes (BGN, CERCAM, TRIP6, and TIMP1) were identified as prognostic markers, with consensus clustering stratifying patients into three molecular subtypes. Cluster C, linked to poor outcomes, exhibited both immune activation and immunosuppressive features. Functional validation showed that BGN and CERCAM promote CRC cell proliferation and metastasis. These findings highlight fibroblasts’ role in CRC progression and suggest BGN and CERCAM as potential immunotherapy targets for precision treatment.

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BIOFACTORS EDITOR’S CHOICE VIRTUAL ISSUE: HIGHLIGHTING TOP PAPERS FROM 2023-2024

BioFactors has recently launched a virtual issue – Editor’s Choice (2023-2024) – featuring a curated selection of high-interest papers published during 2023-2024.

Explore these noteworthy contributions today!

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CALL FOR PAPERS

• Unlocking the Secrets of Lipocalins: Navigating Their Role in Cell Communication and Signalling
  • Submission deadline: Thursday, 31 July 2025
• The Role of Fermented Foods in Nutrition and Health
  • Submission deadline: Thursday, 31 July 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue.
• A short introduction about the significance of the special issue.
• Basic information and CV of Lead Guest Editor and Co-Guest Editors.
• List of potential authors and their tentative article titles.
• The estimated number of submissions.
• Proposed timeline.

Please visit the journal homepage for more information.

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Biotechnology and Applied Biochemistry
New Issue: Volume 72, Issue 1

Chitosan-enhanced sensitivity of mercaptoundecanoic acid (MUA)- capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha-synuclein oligomer biomarker in parkinson’s disease

Apaydın BB, Çamoğlu T, Canbek Özdil ZC, Gezen-Ak D, Ege D, Gülsoy M. Chitosan-enhanced sensitivity of mercaptoundecanoic acid (MUA)- capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha-synuclein oligomer biomarker in parkinson’s disease. Biotechnol Appl Biochem. 2025; 72: 150–163.

Alpha-synuclein oligomers play a crucial role in the early diagnosis of Parkinson’s disease (PD). In this study, a mercaptoundecanoic acid (MUA)-capped gold nanorod (GNR)-coated and chitosan (CH)- immobilized fiber optic probe has shown considerable sensitivity of its detection. The proposed U-shaped fiber optic biosensor based on localized surface plasmon resonance (LSPR) was applied to detect α-syn oligomer (OA) biomarker. By analyzing OA concentrations, the biosensor achieved a limit of detection of (LOD) 11 pM within the concentration range of 10–100 pM and the sensitivity value was found as 502.69 Δλ/RIU. Upon analysis of the CV% (coefficient of variation) and accuracy/recovery values, it is revealed that the sensor successfully fulfilled the criteria for success, displaying accuracy/recovery values within the range of 80%–120% and CV% values below 20%. This sensor presents significant advantages, including high sensitivity, specificity, and ability to detect very low concentrations of OA. In conclusion, the suggested U-shaped fiber optic biosensor has the potential to be valuable in the early detection of PD from a clinical perspective.

CALL FOR PAPERS

Emerging Techniques and Technologies in Healthcare

The purpose of the special issue is to decipher the importance of ground-breaking techniques incorporated in cellular and molecular biology and embrace AI augmented healthcare delivery system. The convergence of these scientific innovations would help translational research reach new heights in the future generation.

Topics for this call for papers include but are not restricted to:

• Importance of Emerging Techniques and Technologies in Health Research
• Genetics and Genomics in Healthcare Research
• Application of Proteomics in Healthcare Research
• Technological Advancements in Cell Biology for Health Research
• Artificial Intelligence in Transforming Medicinal Practice
• Machine Learning and Deep Learning in Healthcare
• Molecular techniques in Disease Detection
• Biochemical parameters for disease detection
• Infectious Disease and Mitigation
• Stem Cell Therapeutics
• Ethical Concerns in Artificial Intelligence Mediated Healthcare Delivery

Deadline for Submissions: 15 May 2025

Guest Editors: Dr. Debasmita Bhattacharya, Institute of Engineering and Management, India; Dr. Dibyajit Lahiri, University of Engineering & Mangement, Kolkata, India; Assoc. Prof. Edinur Hisham Atan, Universiti Sains Malaysia, Malaysia; Prof. Mojgan Rezvani, Durham College, Canada.

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Biochemistry and Molecular Biology Education
New Issue: Volume 53, Issue 2

Improving the learning experience in an undergraduate course on microbial metabolism by using an illustrated story

McKinlay JB, Kearns K. Improving the learning experience in an undergraduate course on microbial metabolism by using an illustrated story. Biochem Mol Biol Educ. 2025; 53(2): 131–141.

In the classroom, metabolism is often approached and received as a mundane exercise in memorization. Teaching metabolism also faces the challenge of negative perceptions that can impede learning. We sought to improve the learning experience in an undergraduate lecture course on microbial metabolism by implementing an illustrated story that follows an Escherichia coli cell during a cholera outbreak. Feedback from students, compiled over four semesters of relatively minimal intervention, suggests that attitudes improved. Most students also thought that storytelling helped them learn. Exam scores suggested that the story could have had a positive performance impact for some questions that required students to apply correct details to specific situations. Our results suggest that a story could improve the learning experience in a course on a traditionally unpopular topic by both improving emotional responses to the subject matter and by providing a familiar framework upon which to contextualize details.

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Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

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Molecular Aspects of Medicine

Aspects of Molecular Medicine

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!

IUBMB Life
New Issue: Volume 77, Issue 1

Ethical bioprospecting and microbial assessments for sustainable solutions to the AMR crisis

Cartledge K, Short FL, Hall A, Lambert K, McDonald MJ, Lithgow T. Ethical bioprospecting and microbial assessments for sustainable solutions to the AMR crisis. IUBMB Life. 2025; 77(1):e2931.

Antimicrobial resistance (AMR) is a major global health challenge, recognized by the WHO and World Bank as a crisis affecting health, finance, and agriculture. AMR arises when microbes evolve resistance to antimicrobial treatments, leading to dangerous infections. While scientific advancements, such as bacteriophage therapy, offer potential solutions, tackling AMR requires a global, multi-sectoral approach. Access to biodiversity and traditional knowledge is crucial for developing new therapies, necessitating ethical partnerships. Widespread awareness and behavioral change across diverse societies are essential to implementing sustainable solutions and preventing the further evolution of AMR.

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SPECIAL ISSUES OPEN FOR SUBMISSION

• Special Issue on Discovering Novel Druggable Targets Using Integrated Omics Approaches
  • Deadline for Submissions: 30 March 2025
• Special Issue on Advancing Translation of Cell-Based Therapeutics in Human Disease: Integrating Specific Modes of Action and Emerging Engineering Approaches
  • Deadline for Submissions: 31 March 2025
• Special Issue on Computational Biology in Identification of Potential Biomarkers for Cancer Immunotherapy
  • Deadline for Submissions: 31 July 2025

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue;
• A short introduction about the significance of the special issue;
• Basic information and CV of Lead Guest Editor and Co-Guest Editors;
• List of potential authors and their tentative article titles;
• The estimated number of submissions;
• Proposed timeline.

Please visit the journal homepage for more information.

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BioFactors
New Issue: Volume 51, Issue 1

Propolis suppresses atopic dermatitis through targeting the MKK4 pathway

Cho Y-R, Han EJ, Heo E, Jayasinghe AMK, Won J, Lee S, et al. Propolis suppresses atopic dermatitis through targeting the MKK4 pathway. BioFactors. 2025; 51(1):e2119.

Propolis, a resinous substance made by bees, is recognized for its health benefits, but its effects on atopic dermatitis (AD) remain unclear. This study explored propolis’s potential in treating AD and identified its active compound and molecular target. In HaCaT keratinocytes, propolis reduced TNF-α-induced IL-6 and IL-8 secretion, lowered chemokine levels (MCP-1, MDC), and restored barrier proteins (filaggrin, involucrin). Similar effects were observed in AD-like human skin, where propolis suppressed AD markers and improved barrier function. In DNCB-induced mice, oral propolis alleviated AD symptoms, reduced scratching and TEWL, and normalized AD-related mRNA levels. These effects were linked to caffeic acid phenethyl ester (CAPE), which selectively targeted MKK4. These findings suggest propolis may serve as a functional food for AD treatment.

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BIOFACTORS EDITOR’S CHOICE VIRTUAL ISSUE: HIGHLIGHTING TOP PAPERS FROM 2023-2024

BioFactors has recently launched a virtual issue – Editor’s Choice (2023-2024) – featuring a curated selection of high-interest papers published during 2023-2024.

Explore these noteworthy contributions today!

—

CALL FOR PAPERS

• Uncovering biomarkers in the tumor-immune microenvironment and analyzing their potential regulatory mechanisms
  • Submission deadline: Sunday, 30 March 2025
• Unlocking the Secrets of Lipocalins: Navigating Their Role in Cell Communication and Signalling
  • Submission deadline: Thursday, 31 July 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue.
• A short introduction about the significance of the special issue.
• Basic information and CV of Lead Guest Editor and Co-Guest Editors.
• List of potential authors and their tentative article titles.
• The estimated number of submissions.
• Proposed timeline.

Please visit the journal homepage for more information.

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Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 6

Effect of tannic acid on doxorubicin-induced cellular stress: Expression levels of heat shock genes in rat spleen

Kizir D, Karaman M, Demir Y, Ceylan H. Effect of tannic acid on doxorubicin-induced cellular stress: Expression levels of heat shock genes in rat spleen. Biotechnol Appl Biochem. 2024; 71: 1339– 1345.

Doxorubicin (DOX), an anthracycline group antibiotic, has been extensively employed as a potent chemotherapeutic agent for treating solid and hematopoietic tumors in humans. Amid exposure to diverse stress conditions, living organisms swiftly initiate the synthesis of heat shock proteins (HSPs), a set of highly conserved proteins. Tannic acid (TA) has garnered increasing study attention due to its special chemical properties, health benefits, and wide availability. This study’s primary aim is to elucidate the impact of DOX and TA on the expression levels of Hsp90aa1, Hspa1a, Hspa4, and Hspa5 in the spleen tissues of rats. These findings suggest that TA may serve as a protective agent, mitigating the toxic effects of DOX in the rat spleen.

CALL FOR PAPERS

Emerging Techniques and Technologies in Healthcare

The purpose of the special issue is to decipher the importance of ground-breaking techniques incorporated in cellular and molecular biology and embrace AI augmented healthcare delivery system. The convergence of these scientific innovations would help translational research reach new heights in the future generation.

Topics for this call for papers include but are not restricted to:

• Importance of Emerging Techniques and Technologies in Health Research
• Genetics and Genomics in Healthcare Research
• Application of Proteomics in Healthcare Research
• Technological Advancements in Cell Biology for Health Research
• Artificial Intelligence in Transforming Medicinal Practice
• Machine Learning and Deep Learning in Healthcare
• Molecular techniques in Disease Detection
• Biochemical parameters for disease detection
• Infectious Disease and Mitigation
• Stem Cell Therapeutics
• Ethical Concerns in Artificial Intelligence Mediated Healthcare Delivery

Deadline for Submissions: 15 May 2025

Guest Editors: Dr. Debasmita Bhattacharya, Institute of Engineering and Management, India; Dr. Dibyajit Lahiri, University of Engineering & Mangement, Kolkata, India; Assoc. Prof. Edinur Hisham Atan, Universiti Sains Malaysia, Malaysia; Prof. Mojgan Rezvani, Durham College, Canada.

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Biochemistry and Molecular Biology Education
New Issue: Volume 53, Issue 1

An undergraduate research experience in CRISPR-Cas9 mediated eukaryotic genome editing to teach fundamental biochemistry techniques

Tonsager AJ, Stargell LA. An undergraduate research experience in CRISPR-Cas9 mediated eukaryotic genome editing to teach fundamental biochemistry techniques. Biochem Mol Biol Educ. 2025; 53(1): 33– 45.

CRISPR-Cas9 technology is an established, powerful tool for genome editing through the ability to target specific DNA sequences of interest for introduction of desired genetic modifications. CRISPR-Cas9 is utilized for a variety of purposes, ranging from a research molecular biology tool to treatment for human diseases. Due to its prominence across a variety of applications, it is critical that undergraduates in the life sciences are educated on CRISPR-Cas9 technology. To this end, we created an intensive eight-week long course-based undergraduate research experience (CURE) designed for students to understand CRISPR-Cas9 genome editing and perform it in Saccharomyces cerevisiae.

E!Canasta: A card game to teach ATP synthesis and metabolic regulation in biochemistry classes

Thalles Henrique Faria de Souza, Eduardo Figueiredo Peloso, Gabriel Gerber Hornink

Understanding ATP formation is essential for learning metabolism and is central to grasping metabolic processes as a whole. However, due to the high level of abstraction, the number of intermediate substrates, the connections, and integrated regulation, its comprehension often poses a challenge. This and the fact that traditional teaching methods struggle when dealing with highly abstract concepts, game-based strategies present a more concrete and dynamic alternative, which led to the creation of E!Canasta (card game). Developed based on Canasta and adapted in order to improve the learning of concepts, including some of pathway’s regulation and integration, E!Canasta motivates students and promotes engagement in a fun activity. Students assemble a sequence of cards representing the glycolysis, acetyl-CoA, Krebs cycle, and electron transport chain, which correspond to the card suits. Strategically, some of the cards hold special feats that simulate some aspects of metabolic regulation and integration (to give or take away points). At the end of the game, points are added up for sequences and cards with positive or negative effects. The game was played with two classes of students enrolled in biochemistry as part of their graduations (86 players). Student perception on gameplay, motivation and understanding was measured through an anonymous Likert scale questionnaire, with very positive results in all questions. Statistically significant correlations were observed regarding the perceived comprehension of pathways and their regulation, and in linking motivation with a positive gaming experience, showcasing that E!Canasta demonstrates considerable educational potential, along with an enjoyable experience for learning ATP synthesis.

VIRTUAL SPECIAL ISSUE

Diversity, Equity, Inclusion, Justice, and Access (DEIJA) in Molecular Life Sciences Education: Biochemistry and Molecular Biology Education

Daniel R. Dries, Rou-Jia Sung

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Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

---

Molecular Aspects of Medicine

Aspects of Molecular Medicine

Dear Friends of the IUBMB,

During the celebration of the 60th Anniversary of the Federation of European Biochemical Societies (FEBS) in Milan in June 2024, the Milan Declaration was developed by FEBS, IUBMB, FASBMB, FAOBMB and PABMB on 29th June 2024. The Milan Declaration focuses on the Crucial Role of Science in meeting the Global Challenges and stresses the importance of Science and Scientific Research in providing coordinated solutions to global problems and challenges. I am pleased to inform you that the Milan Declaration page is now live (https://www.febs.org/milan-declaration-science/). We hope to gather a significant number of signatures from our members during the next month so that we can initiate a promotional campaign aimed at the general public and the media.  

We strongly encourage you to utilize the attached call to action kit to reach out to members of your Societies, encouraging them to sign the declaration online as individuals and to promote it through your platforms (website, social media, newsletters).

Thank you for your commitment to making this initiative a success and in assisting in the global spreading the mission of the Milan Declaration.

Many thanks and best wishes,
The IUBMB

online flyer

 

The Federation of European Biochemical Societies (FEBS) and the International Union of Biochemistry and Molecular Biology (IUBMB) are pleased to announce the call for host institution of the 5th edition of the FEBS-IUBMB-ENABLE Conference – an international, interdisciplinary 3-day PhD and Postdoc meeting.

We are seeking a motivated partner to join our team as a host of the 5th FEBS-IUBMB-ENABLE Conference, in autumn 2026 – the call is open for all molecular life sciences academic and research institution institutions from the countries with a FEBS Constituent Society.

Do you have an active PhD and postdoc community? Do you, as an institution, want to promote hands-on event organization training to your young researchers?

FEBS-IUBMB-ENABLE Conferences are a unique opportunity to immerse young researchers in organizational and project management skills by organizing an entire scientific symposium by themselves. Based on the successful project ENABLE (https://febs-iubmb-enableconference.org), the FEBS-IUBMB-ENABLE conference series has emerged as a joint initiative of FEBS, IUBMB, and several leading biomedical research institutes across Europe to continue, reinforce and spread the spirit of ENABLE and biomedical sciences across the world.

 

Guidelines and application forms for host institutions:

Application Guidelines   |  2026 Application Form   |  Budget Form

 

Application deadline: 28 February 2025

Read more about eligibility and requirements and how to apply

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!

IUBMB Life
New Issue: Volume 77, Issue 1

Depletion of macrophages and osteoclast precursors mitigates iron overload-mediated bone loss

Passin V, Ledesma-Colunga MG, Altamura S, Muckenthaler MU, Baschant U, Hofbauer LC, et al. Depletion of macrophages and osteoclast precursors mitigates iron overload-mediated bone loss. IUBMB Life. 2025; 77(1):e2928

Iron is vital for cellular processes but toxic in excess, with iron overload often linked to low bone mass. Both increased bone resorption by osteoclasts and decreased bone formation by osteoblasts contribute to bone loss, though the specific role of osteoclast precursors remains unclear. This study investigated their role in iron overload-induced bone loss using clodronate liposomes to deplete phagocytic cells, including osteoclast precursors, in iron-treated mice.

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SPECIAL ISSUES OPEN FOR SUBMISSION

• Special Issue on Discovering Novel Druggable Targets Using Integrated Omics Approaches
  • Deadline for Submissions: 30 March 2025
• Special Issue on Advancing Translation of Cell-Based Therapeutics in Human Disease: Integrating Specific Modes of Action and Emerging Engineering Approaches
  • Deadline for Submissions: 31 March 2025
• Special Issue on Computational Biology in Identification of Potential Biomarkers for Cancer Immunotherapy
  • Deadline for Submissions: 31 July 2025

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue;
• A short introduction about the significance of the special issue;
• Basic information and CV of Lead Guest Editor and Co-Guest Editors;
• List of potential authors and their tentative article titles;
• The estimated number of submissions;
• Proposed timeline.

Please visit the journal homepage for more information.

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BioFactors
New Issue: Volume 51, Issue 1

Fisetin is a selective adenosine triphosphate-competitive inhibitor for mitogen-activated protein kinase kinase 4 to inhibit lipopolysaccharide-stimulated inflammation

Muhammad Asim, Ziyu He, He Z, Uto T, Tanigawa S, Sakao K, Kumamoto T, Xie K, et al. Fisetin is a selective adenosine triphosphate- competitive inhibitor for mitogen-activated protein kinase kinase 4 to inhibit lipopolysaccharide- stimulated inflammation. BioFactors. 2025; 51(1):e2108.

MKK4, a kinase activating the JNK pathway in response to inflammation and stress, is a potential therapeutic target for inflammation. This study investigated whether fisetin, an anti-inflammatory compound, inhibits the MKK4-JNK cascade to suppress lipopolysaccharide (LPS)-induced inflammation. Using RAW264 macrophages, fisetin dose-dependently reduced COX-2 gene expression and PGE2 secretion by selectively inhibiting MKK4-JNK1/2 signaling and AP-1 phosphorylation without affecting NF-κB or Jak2-Stat3 pathways.

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BIOFACTORS EDITOR’S CHOICE VIRTUAL ISSUE: HIGHLIGHTING TOP PAPERS FROM 2023-2024

BioFactors has recently launched a virtual issue – Editor’s Choice (2023-2024) – featuring a curated selection of high-interest papers published during 2023-2024.

Explore these noteworthy contributions today!

—

CALL FOR PAPERS

• Uncovering biomarkers in the tumor-immune microenvironment and analyzing their potential regulatory mechanisms
  • Submission deadline: Sunday, 30 March 2025
• Unlocking the Secrets of Lipocalins: Navigating Their Role in Cell Communication and Signalling
  • Submission deadline: Thursday, 31 July 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue.
• A short introduction about the significance of the special issue.
• Basic information and CV of Lead Guest Editor and Co-Guest Editors.
• List of potential authors and their tentative article titles.
• The estimated number of submissions.
• Proposed timeline.

Please visit the journal homepage for more information.

---

Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 6

Identification of a novel anti-ROR1 nanobody through phage display and its biochemical characterization

Kang L, Dong Y, Wang W, Li Z, Wang Y, Yan L, et al. Identification of a novel anti-ROR1 nanobody through phage display and its biochemical characterization. Biotechnol Appl Biochem. 2024; 71: 1226–1234.

In this study, the authors aimed to develop nanobodies targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1) for cancer diagnosis and therapy. The authors immunized alpacas with ROR1, extracted RNA from their blood, and converted it to complementary DNA (cDNA) to amplify the VHH (variable domain of heavy-chain antibodies) sequence. This sequence was used to construct a phage library with a capacity of 8 ×10⁸. Screening identified a high-affinity nanobody, HCAbs1, which binds effectively to ROR1. ELISA and surface plasmon resonance analyses revealed HCAbs1’s binding affinities to ROR1 at 4.42 and 12.9 nM, respectively. Functional tests showed HCAbs1 could reduce extracellular signal-regulated kinase (ERK) phosphorylation levels induced by Wnt5a in ROR1-transfected cells. Our findings highlight the potential of HCAbs1 nanobodies in diagnosing and treating cancers through targeting ROR1.

CALL FOR PAPERS

Emerging Techniques and Technologies in Healthcare

The purpose of the special issue is to decipher the importance of ground-breaking techniques incorporated in cellular and molecular biology and embrace AI augmented healthcare delivery system. The convergence of these scientific innovations would help translational research reach new heights in the future generation.

Topics for this call for papers include but are not restricted to:

• Importance of Emerging Techniques and Technologies in Health Research
• Genetics and Genomics in Healthcare Research
• Application of Proteomics in Healthcare Research
• Technological Advancements in Cell Biology for Health Research
• Artificial Intelligence in Transforming Medicinal Practice
• Machine Learning and Deep Learning in Healthcare
• Molecular techniques in Disease Detection
• Biochemical parameters for disease detection
• Infectious Disease and Mitigation
• Stem Cell Therapeutics
• Ethical Concerns in Artificial Intelligence Mediated Healthcare Delivery

Deadline for Submissions: 15 May 2025

Guest Editors: Dr. Debasmita Bhattacharya, Institute of Engineering and Management, India; Dr. Dibyajit Lahiri, University of Engineering & Mangement, Kolkata, India; Assoc. Prof. Edinur Hisham Atan, Universiti Sains Malaysia, Malaysia; Prof. Mojgan Rezvani, Durham College, Canada.

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Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 6

A primer for junior trainees: Recognition of RNA modifications by RNA-binding proteins

Angelo M, Bhargava Y, Aoki ST. A primer for junior trainees: Recognition of RNA modifications by RNA- binding proteins. Biochem Mol Biol Educ. 2024; 52(6): 701–710.

The complexity of RNA cannot be fully expressed with the canonical A, C, G, and U alphabet. To date, over 170 distinct chemical modifications to RNA have been discovered in living systems. RNA modifications can profoundly impact the cellular outcomes of messenger RNAs (mRNAs), transfer and ribosomal RNAs, and noncoding RNAs. Additionally, aberrant RNA modifications are associated with human disease. The role of RNA modifications in gene regulation, disease pathogenesis, and therapeutic applications increasingly captures the attention of the scientific community. This review aims to provide undergraduates, junior trainees, and educators with an appreciation for the significance of RNA modifications in eukaryotic organisms, alongside the skills required to identify and analyze fundamental RNA–protein interactions. By instilling these foundational, textbook concepts through practical

examples, this review contributes an analytical toolkit that facilitates engagement with RNA modifications research at large.

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Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

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Molecular Aspects of Medicine

Aspects of Molecular Medicine

Our December Newsletter highlights IUBMB activities including a note from the President and updates on the IUBMB Trainee Initiative.

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!

IUBMB Life
New Issue: Volume 76, Issue 11

Pore-forming aegerolysin and MACPF proteins in extremotolerant or extremophilic fungi

Kraševec N. Pore-forming aegerolysin and MACPF proteins in extremotolerant or extremophilic fungi. IUBMB Life. 2024; 76(11): 922–936.

Aegerolysin proteins are involved in various interactions by recognising a molecular receptor in the target organism. The formation of pores in combination with larger, non-aegerolysin-like protein partners is one of the possible responses in the presumed competitive exclusion of other organisms from the ecological niche. Fungi growing under extreme conditions can be divided into ubiquitous and extremotolerant generalists which can compete with mesophilic species and rare, isolated extremophilic and extremotolerant specialists with narrow ecological amplitude that cannot compete. Under extreme conditions, there are fewer competitors, so fungal specialists generally produce less diverse and complicated profiles of specialised molecules. Since extremotolerant and extremophilic fungi have evolved in numerous branches of the fungal tree of life and aegerolysins are unevenly distributed across fungal genomes, the author investigated whether aegerolysins, together with their partner proteins, contribute to the extreme survival ecology of generalists and specialists.

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SPECIAL ISSUES OPEN FOR SUBMISSION

• Special Issue on Viruses and Cell Metabolism
  • Deadline for Submissions: 30 November 2024
• Special Issue on Tumor Microenvironment: Explorations and Interventions
  • Deadline for Submissions: 10 December 2024
• Special Issue on Discovering Novel Druggable Targets Using Integrated Omics Approaches
  • Deadline for Submissions: 30 March 2025
• Special Issue on Advancing Translation of Cell-Based Therapeutics in Human Disease: Integrating Specific Modes of Action and Emerging Engineering Approaches
  • Deadline for Submissions: 31 March 2025
• Special Issue on Computational Biology in Identification of Potential Biomarkers for Cancer Immunotherapy
  • Deadline for Submissions: 31 July 2025

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue;
• A short introduction about the significance of the special issue;
• Basic information and CV of Lead Guest Editor and Co-Guest Editors;
• List of potential authors and their tentative article titles;
• The estimated number of submissions;
• Proposed timeline.

Please visit the journal homepage for more information.

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BioFactors
New Issue: Volume 50, Issue 5

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

Bhale AS, Meilhac O, d’Hellencourt CL, Vijayalakshmi MA, Venkataraman K. BioFactors. 2024; 50(4): 50(5): 922–956.

High-density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and inflammation modulation. The proteome of HDL particles is indeed complex and distinct from other components in the bloodstream. Proteomics studies have identified nearly 285 different proteins associated with HDL; however, this review focuses more on the 15 or so traditionally named “apo” lipoproteins. Understanding the nature of all 15 apolipoproteins expands our knowledge of HDL metabolism, sheds light on their pathological implications, and paves the way for advancements in the diagnosis, prevention, and treatment of lipid and inflammatory-related disorders.

—

CALL FOR PAPERS

Uncovering biomarkers in the tumor-immune microenvironment and analyzing their potential regulatory mechanisms

Submission deadline: Sunday, 30 March 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue.
• A short introduction about the significance of the special issue.
• Basic information and CV of Lead Guest Editor and Co-Guest Editors.
• List of potential authors and their tentative article titles.
• The estimated number of submissions.
• Proposed timeline.

Please visit the journal homepage for more information.

Welcome to a new Editorial Board Member!
Dr. Camilla Morresi – Polytecnic University of Marche, Italy

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Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 4

CALL FOR PAPERS

Leveraging Genomics Data in Blockchain for Medical Research Ethics

The Special Issue aims to create a dialogue on leveraging genomics data in blockchain for medical research ethics. Also, we plan to attract researchers with a diverse range of studies that explore theoretical frameworks, technological innovations, policy analyses, and case studies demonstrating practical applications and challenges.

Topics for this call for papers include but are not restricted to:

• Ethical frameworks for genomic data ownership and sharing on blockchain platforms;
• Technological advancements in secure and scalable blockchain systems for genomic data;
• Interoperability challenges and solutions in integrating genomics with different blockchain architectures;
• Regulatory landscape and policy recommendations for blockchain in genomics;
• Economic models for incentivizing the sharing of genomic data on blockchain platforms;
• Impact assessments of blockchain on the speed and efficacy of medical research;
• Legal implications of decentralized genomic data management;
• Ethical considerations in the use of smart contracts for genomic data consent management;
• Comparative analyses of global initiatives employing blockchain for genomics;
• Challenges and strategies for educating stakeholders about the benefits and risks of blockchain in genomics;
• Future prospects of integrating artificial intelligence with blockchain and genomics for advanced medical research;
• Privacy-preserving techniques for genomic data on blockchain: challenges and future directions;
• Case studies of blockchain applications in enhancing privacy and consent in genomics research.

Deadline for Submissions: 1 December 2025

Guest Editors: Dr Muzammil Hussain (Lead), Pakistan; Dr Muhammad Adnan Khan, Gachon University, The Republic of Korea; Dr Kiran Adnan, Malaysia

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Emerging Techniques and Technologies in Healthcare

The purpose of the special issue is to decipher the importance of ground-breaking techniques incorporated in cellular and molecular biology and embrace AI augmented healthcare delivery system. The convergence of these scientific innovations would help translational research reach new heights in the future generation.

Topics for this call for papers include but are not restricted to:

• Importance of Emerging Techniques and Technologies in Health Research
• Genetics and Genomics in Healthcare Research
• Application of Proteomics in Healthcare Research
• Technological Advancements in Cell Biology for Health Research
• Artificial Intelligence in Transforming Medicinal Practice
• Machine Learning and Deep Learning in Healthcare
• Molecular techniques in Disease Detection
• Biochemical parameters for disease detection
• Infectious Disease and Mitigation
• Stem Cell Therapeutics
• Ethical Concerns in Artificial Intelligence Mediated Healthcare Delivery

Deadline for Submissions: 15 May 2025

Guest Editors: Dr. Debasmita Bhattacharya, Institute of Engineering and Management, India; Dr. Dibyajit Lahiri, University of Engineering & Mangement, Kolkata, India; Assoc. Prof. Edinur Hisham Atan, Universiti Sains Malaysia, Malaysia; Prof. Mojgan Rezvani, Durham College, Canada.

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Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 5

A cost-effective enzyme kinetics and inhibition model for biochemistry education and research

VanDee L, Teague A, East T, Jacinto KR, Carter M, Totty J, et al. Biochem Mol Biol Educ. 2024; 52(5): 588–598.

Enzyme kinetics and inhibition studies are crucial in biochemistry education and research. Conventional methods often require expensive equipment and reagents, potentially limiting their accessibility in limited resource settings. Our approach sought to develop a cost-effective experimental design for studying enzyme kinetics and inhibition. Lactase was chosen as a protein model and its activity was investigated by measuring glucose production from lactose hydrolysis. In the study, commercially available lactase pills were used as an enzyme source, while milk was used as a substrate. Instead of scientific equipment, glucometers were used to measure lactase activity. Enzyme kinetics were evaluated using Michaelis–Menten and Lineweaver–Burk plots. In the study, the effects of temperature, pH, and inhibitors were also investigated. The approach presented here offers a cost-effective procedure for studying enzyme kinetics and inhibition. It can act as a valuable tool for educational purposes and for preliminary research in settings with limited resources.

---

Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

---

Molecular Aspects of Medicine

Aspects of Molecular Medicine

We are excited to highlight new research from the IUBMB Journals: IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education.

Please also consider submitting your own research to the IUBMB Journals. You can expect to work with distinguished Editorial Board members and benefit from worldwide circulation and readership through our publishing partnership with Wiley. For more information about the journal and submissions, feel free to peruse the IUBMB journals website.

For now, please enjoy highlights of our recent content. Happy reading!
• Disease causing gene mutations
• Human Genetic Disorders
• Therapeutic strategies targeting disease-associated mutations

IUBMB Life
New Issue: Volume 76, Issue 10

Issue Highlights (Subscription Only)

The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells

Wang H, Li J, Yu K, Lu Y, Ma M, Li Y. IUBMB Life. 2024; 6(10): 764–779.

The Angiomotin (AMOT) family includes AMOT, AMOTL1, and AMOTL2, with AMOTL2 being expressed in endothelial, epithelial, and cancer cells. AMOTL2 localizes differently across cell types, regulating tube formation, cell polarity, and shape. In cancer, its role varies: AMOTL2 promotes tumor growth in pancreatic, breast, and colon cancers but inhibits proliferation in lung, liver, and glioblastoma. It influences cytoskeletal dynamics and modulates YAP transcription by binding to it. AMOTL2 is downregulated in some tumors but elevated in colorectal adenocarcinoma (COAD), where it drives oncogenic activity by affecting the Wnt pathway and immune cell infiltration. Further research is needed to clarify its roles in various cancers.

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SPECIAL ISSUES OPEN FOR SUBMISSION

• Special Issue on from DNA to protein: molecular mechanisms and tailored approaches to correct genetic defects associated with human disorders
  • Deadline for Submissions: 31 October 2024
• Special Issue on Viruses and Cell Metabolism
  • Deadline for Submissions: 30 November 2024
• Special Issue on Tumor Microenvironment: Explorations and Interventions
  • Deadline for Submissions: 10 December 2024
• Special Issue on Discovering Novel Druggable Targets Using Integrated Omics Approaches
  • Deadline for Submissions: 30 March 2025
• Special Issue on Advancing Translation of Cell-Based Therapeutics in Human Disease: Integrating Specific Modes of Action and Emerging Engineering Approaches
  • Deadline for Submissions: 31 March 2025

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue;
• A short introduction about the significance of the special issue;
• Basic information and CV of Lead Guest Editor and Co-Guest Editors;
• List of potential authors and their tentative article titles;
• The estimated number of submissions;
• Proposed timeline.

Please visit the journal homepage for more information.

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BioFactors
New Issue: Volume 50, Issue 5

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

Bhale AS, Meilhac O, d’Hellencourt CL, Vijayalakshmi MA, Venkataraman K. BioFactors. 2024; 50(4): 50(5): 922–956.

High-density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and inflammation modulation. The proteome of HDL particles is indeed complex and distinct from other components in the bloodstream. Proteomics studies have identified nearly 285 different proteins associated with HDL; however, this review focuses more on the 15 or so traditionally named “apo” lipoproteins. Understanding the nature of all 15 apolipoproteins expands our knowledge of HDL metabolism, sheds light on their pathological implications, and paves the way for advancements in the diagnosis, prevention, and treatment of lipid and inflammatory-related disorders.

—

CALL FOR PAPERS

Uncovering biomarkers in the tumor-immune microenvironment and analyzing their potential regulatory mechanisms

Submission deadline: Sunday, 30 March 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue.
• A short introduction about the significance of the special issue.
• Basic information and CV of Lead Guest Editor and Co-Guest Editors.
• List of potential authors and their tentative article titles.
• The estimated number of submissions.
• Proposed timeline.

Please visit the journal homepage for more information.

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Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 4

Correlation between plasma PSGL-1 and FIGO stage, tumor metastasis, and survival in epithelial ovarian cancer

Li WH, Fang C, Gao Y, Gao Y, Yan FS, Chen B, et al. Biotechnol Appl Biochem. 2024; 71: 733–740.

Plasma circulating P-selectin glycoprotein ligand-1 (PSGL-1) levels and its clinical correlation in patients with epithelial ovarian cancer (EOC) are unknown. The study determined plasma PSGL-1 levels in EOC patients and investigated its relationship with clinicopathological factors and prognosis. Plasma PSGL-1 levels were measured using ELISA in 69 patients with EOC, 34 patients with benign ovarian cystadenoma, and 36 healthy controls. Subsequently, the relationship between PSGL-1 levels and clinicopathological characteristics of patients, as well as the prognosis of EOC patients, was examined. Additionally, the specificity and sensitivity of plasma PSGL-1 were assessed through ROC curve analysis.

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CALL FOR PAPERS

Leveraging Genomics Data in Blockchain for Medical Research Ethics

The Special Issue aims to create a dialogue on leveraging genomics data in blockchain for medical research ethics. Also, we plan to attract researchers with a diverse range of studies that explore theoretical frameworks, technological innovations, policy analyses, and case studies demonstrating practical applications and challenges.

Topics for this call for papers include but are not restricted to:

• Ethical frameworks for genomic data ownership and sharing on blockchain platforms;
• Technological advancements in secure and scalable blockchain systems for genomic data;
• Interoperability challenges and solutions in integrating genomics with different blockchain architectures;
• Regulatory landscape and policy recommendations for blockchain in genomics;
• Economic models for incentivizing the sharing of genomic data on blockchain platforms;
• Impact assessments of blockchain on the speed and efficacy of medical research;
• Legal implications of decentralized genomic data management;
• Ethical considerations in the use of smart contracts for genomic data consent management;
• Comparative analyses of global initiatives employing blockchain for genomics;
• Challenges and strategies for educating stakeholders about the benefits and risks of blockchain in genomics;
• Future prospects of integrating artificial intelligence with blockchain and genomics for advanced medical research;
• Privacy-preserving techniques for genomic data on blockchain: challenges and future directions;
• Case studies of blockchain applications in enhancing privacy and consent in genomics research.

Deadline for Submissions: 1 December 2024

Guest Editors: Dr Muzammil Hussain (Lead), Pakistan; Dr Muhammad Adnan Khan, Gachon University, The Republic of Korea; Dr Kiran Adnan, Malaysia

—

Emerging Techniques and Technologies in Healthcare

The purpose of the special issue is to decipher the importance of ground-breaking techniques incorporated in cellular and molecular biology and embrace AI augmented healthcare delivery system. The convergence of these scientific innovations would help translational research reach new heights in the future generation.

Topics for this call for papers include but are not restricted to:

• Importance of Emerging Techniques and Technologies in Health Research
• Genetics and Genomics in Healthcare Research
• Application of Proteomics in Healthcare Research
• Technological Advancements in Cell Biology for Health Research
• Artificial Intelligence in Transforming Medicinal Practice
• Machine Learning and Deep Learning in Healthcare
• Molecular techniques in Disease Detection
• Biochemical parameters for disease detection
• Infectious Disease and Mitigation
• Stem Cell Therapeutics
• Ethical Concerns in Artificial Intelligence Mediated Healthcare Delivery

Deadline for Submissions: 15 May 2025

Guest Editors: Dr. Debasmita Bhattacharya, Institute of Engineering and Management, India; Dr. Dibyajit Lahiri, University of Engineering & Mangement, Kolkata, India; Assoc. Prof. Edinur Hisham Atan, Universiti Sains Malaysia, Malaysia; Prof. Mojgan Rezvani, Durham College, Canada.

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Searching for a New Editor-in-Chief for Biotechnology and Applied Biochemistry

The International Union of Biochemistry and Molecular Biology (IUBMB) seeks a new Editor-in-Chief for Biotechnology and Applied Biochemistry. Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of discoveries in the life sciences that impact and advance biotechnology. The Editor will consider papers for publication based on their potential impact on the field, and their compatibility with journal scope. The journal seeks contributions to the fields of synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology, and how they can be applied to medical and industrial biotechnology.

The successful candidate will be recognized as a leading member of the biochemistry and molecular biology community. They will have an outstanding publication record; an extensive, global network; an appreciation for the diverse fields within the journal’s scope; and will represent the diversity within the IUBMB global community.

The successful candidate will have an outstanding opportunity to further develop the journal over a maximum three 3-year terms in the role commencing July 1, 2025. They must demonstrate a clear vision for its future growth and position in the publishing landscape. The appointee will bring extensive experience in peer review and/or editorial roles, high ethical professional standards, innovation, enthusiasm, strong leadership, and organizational and communication skills to the journal.

The main functions within this role are: strategic and practical development of the journal, defining a vision for the content; defining content and commissioning papers for regular and special issues; maintaining editorial standards; providing strong and inspiring leadership to the journal’s editorial board; appointing new board members to grow the journal; promoting the journal; managing the publication, and working closely with IUBMB and the publisher (Wiley). This important leadership role will require a significant time commitment on a weekly basis and will be recompensed accordingly. Associate Editors are appointed to limited terms by the Editors-in-Chief to handle some functions, subject to approval by the IUBMB Executive Committee. The Editor-in-Chief of Biotechnology and Applied Biochemistry will receive an annual honorarium and is supported by professional editorial office assistance.

Applications should include the following

1. A full CV, including details of peer review and/or editorial roles and the applicant’s publication record
2. A brief statement describing your vision for Biotechnology and Applied Biochemistry
3. A cover letter outlining your suitability for the Editor-in-Chief role
4. Two reference Letters

Please send any queries relating to this appointment and applications, in confidence, to: Prof. James Murphy (jamesm@wehi.edu.au), Chair of the IUBMB Publications Committee. Application deadline October 31, 2024.

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Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 5

Enhancing teaching effectiveness in biochemistry labs: Author reflections and improvement strategies

Costabile M, Simpson B, Turkanovic J, Hughes BP. Biochem Mol Biol Educ. 2024; 52(5): 559–568.

This article details the outcome of a joint reflective approach undertaken by the authors to identify common difficulties experienced by 2nd-year undergraduate Biochemistry students in laboratory classes. Difficulties experienced in laboratories can affect the development of hand skills, an understanding of how to correctly operate laboratory equipment and the linkage between didactic content and their experimental demonstration. These difficulties covered were identified based on their common appearance across multiple cohorts and are grouped into five broad areas. The approach and resources developed to address these difficulties may help other Biochemistry educators who are facing similar experiences with their undergraduate students.

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Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

---

Molecular Aspects of Medicine

Aspects of Molecular Medicine

IUBMB Life
New Issue: Volume 76, Issue 8

Evolution and variation in amide aminoacyl-tRNA synthesis

Lewis AM, Fallon T, Dittemore GA, Sheppard K. IUBMB Life. 2024; 76(8): 505-522.

The amide proteogenic amino acids, asparagine and glutamine, are two of the twenty amino acids used in translation by all known life. The aminoacyl-tRNA synthetases for asparagine and glutamine, asparaginyl-tRNA synthetase and glutaminyl tRNA synthetase, evolved after the split in the last universal common ancestor of modern organisms. Before that split, life used two-step indirect pathways to synthesize asparagine and glutamine on their cognate tRNAs to form the aminoacyl-tRNA used in translation. These two-step pathways were retained throughout much of the bacterial and archaeal domains of life and eukaryotic organelles. The indirect routes use non-discriminating aminoacyl-tRNA synthetases (non-discriminating aspartyl-tRNA synthetase and non-discriminating glutamyl-tRNA synthetase) to misaminoacylate the tRNA. The misaminoacylated tRNA formed is then transamidated into the amide aminoacyl-tRNA used in protein synthesis by tRNA-dependent amidotransferases (GatCAB and GatDE). The enzymes and tRNAs involved assemble into complexes known as transamidosomes to help maintain translational fidelity. These pathways have evolved to meet the varied cellular needs across a diverse set of organisms, leading to significant variation. In certain bacteria, the indirect pathways may provide a means to adapt to cellular stress by reducing the fidelity of protein synthesis. The retention of these indirect pathways versus acquisition of asparaginyl-tRNA synthetase and glutaminyl tRNA synthetase in lineages likely involves a complex interplay of the competing uses of glutamine and asparagine beyond translation, energetic costs, co-evolution between enzymes and tRNA, and involvement in stress response that await further investigation.

Nano-therapeutics: The upcoming nanomedicine to treat cancer

Khan H, Shahab U, Alshammari A, Alyahyawi AR, Akasha R, Alharazi T, et al. IUBMB Life. 2024; 76(8): 468-484.

Nanotechnology is considered a successful approach for cancer diagnosis and treatment. Preferentially, cancer cell recognition and drug targeting via nano-delivery system include the penetration of anticancer agents into the cell membrane to damage the cancer cell by protein modification, DNA oxidation, or mitochondrial dysfunction. The past research on nano-delivery systems and their target has proven the beneficial achievement in a malignant tumor. This review focuses on using a nano-delivery system, an imaging system, and encapsulated nanoparticles for cancer therapy.

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SPECIAL ISSUES OPEN FOR SUBMISSION

• Special Issue on Environmental Management and Biomedical Research
  • Deadline for Submissions: 20 September 2024
• Special Issue on from DNA to protein: molecular mechanisms and tailored approaches to correct genetic defects associated with human disorders
  • Deadline for Submissions: 31 October 2024
• Special Issue on Viruses and Cell Metabolism
  • Deadline for Submissions: 30 November 2024
• Special Issue on Tumor Microenvironment: Explorations and Interventions
  • Deadline for Submissions: 10 December 2024
• Special Issue on Discovering Novel Druggable Targets Using Integrated Omics Approaches
  • Deadline for Submissions: 30 March 2025
• Special Issue on Advancing Translation of Cell-Based Therapeutics in Human Disease: Integrating Specific Modes of Action and Emerging Engineering Approaches
  • Deadline for Submissions: 31 March 2025

CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue;
• A short introduction about the significance of the special issue;
• Basic information and CV of Lead Guest Editor and Co-Guest Editors;
• List of potential authors and their tentative article titles;
• The estimated number of submissions;
• Proposed timeline.

Please visit the journal homepage for more information.

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BioFactors
New Issue: Volume 50, Issue 4

Sulforaphane prevents diabetes-induced hepatic ferroptosis by activating Nrf2 signaling axis

Savic N, Markelic M, Stancic A, Velickovic K, Grigorov I, Vucetic M, et al. BioFactors. 2024; 50(4): 810–827.

Recently, the authors have characterized the ferroptotic phenotype in the liver of diabetic mice and revealed nuclear factor (erythroid-derived-2)-related factor 2 (Nrf2) inactivation as an integral part of hepatic injury. Here, the authors aim to investigate whether sulforaphane, an Nrf2 activator and antioxidant, prevents diabetes-induced hepatic ferroptosis and the mechanisms involved.

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CALL FOR PAPERS

Uncovering biomarkers in the tumor-immune microenvironment and analyzing their potential regulatory mechanisms

Topics for this call for papers include but are not restricted to:

• Identification and validation of biomarkers for cancer diagnosis, prognosis, and treatment personalization
• Novel biomarkers of immunotherapy response or resistance
• Advances in technologies for profiling tumor-immune interactions
• The application of genomics and other omics technologies in understanding the heterogeneity of solid tumors
• Therapeutic strategies targeting the immune system in cancer

Submission deadline: Sunday, 30 March 2025

CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue.
• A short introduction about the significance of the special issue.
• Basic information and CV of Lead Guest Editor and Co-Guest Editors.
• List of potential authors and their tentative article titles.
• The estimated number of submissions.
• Proposed timeline.

Please visit the journal homepage for more information.

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Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 4

The effects of hyaluronan and proteoglycan link protein 1 (HAPLN1) in ameliorating spinal cord injury mediated by Nrf2

Yang H, Hu B, Wang X, Chen W, Zhou H. Biotechnol Appl Biochem. 2024; 71: 929–939.

Excessive inflammatory response and oxidative stress (OS) play an important role in the pathogenesis of spinal cord injury (SCI). Balance of inflammation and prevention of OS have been considered an effective strategy for the treatment of SCI. Hyaluronan and proteoglycan link protein 1 (HAPLN1), also known as cartilage link protein, has displayed a wide range of biological and physiological functions in different types of tissues and cells. However, whether HAPLN1 regulates inflammation and OS during SCI is unknown. Therefore, the authors aimed to examine whether HAPLN1 can have a protective effect on SCI. In this study, both in vitro and in vivo SCI models were established.

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CALL FOR PAPERS

Leveraging Genomics Data in Blockchain for Medical Research Ethics

The Special Issue aims to create a dialogue on leveraging genomics data in blockchain for medical research ethics. Also, we plan to attract researchers with a diverse range of studies that explore theoretical frameworks, technological innovations, policy analyses, and case studies demonstrating practical applications and challenges.

Topics for this call for papers include but are not restricted to:

• Ethical frameworks for genomic data ownership and sharing on blockchain platforms;
• Technological advancements in secure and scalable blockchain systems for genomic data;
• Interoperability challenges and solutions in integrating genomics with different blockchain architectures;
• Regulatory landscape and policy recommendations for blockchain in genomics;
• Economic models for incentivizing the sharing of genomic data on blockchain platforms;
• Impact assessments of blockchain on the speed and efficacy of medical research;
• Legal implications of decentralized genomic data management;
• Ethical considerations in the use of smart contracts for genomic data consent management;
• Comparative analyses of global initiatives employing blockchain for genomics;
• Challenges and strategies for educating stakeholders about the benefits and risks of blockchain in genomics;
• Future prospects of integrating artificial intelligence with blockchain and genomics for advanced medical research;
• Privacy-preserving techniques for genomic data on blockchain: challenges and future directions;
• Case studies of blockchain applications in enhancing privacy and consent in genomics research.

Deadline for Submissions: 1 December 2024

Guest Editors: Dr Muzammil Hussain (Lead), Pakistan; Dr Muhammad Adnan Khan, Gachon University, The Republic of Korea; Dr Kiran Adnan, Malaysia

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Searching for a New Editor-in-Chief for Biotechnology and Applied Biochemistry

The International Union of Biochemistry and Molecular Biology (IUBMB) seeks a new Editor-in-Chief for Biotechnology and Applied Biochemistry. Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of discoveries in the life sciences that impact and advance biotechnology. The Editor will consider papers for publication based on their potential impact on the field, and their compatibility with journal scope. The journal seeks contributions to the fields of synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology, and how they can be applied to medical and industrial biotechnology.

The successful candidate will be recognized as a leading member of the biochemistry and molecular biology community. They will have an outstanding publication record; an extensive, global network; an appreciation for the diverse fields within the journal’s scope; and will represent the diversity within the IUBMB global community.

The successful candidate will have an outstanding opportunity to further develop the journal over a maximum three 3-year terms in the role commencing July 1, 2025. They must demonstrate a clear vision for its future growth and position in the publishing landscape. The appointee will bring extensive experience in peer review and/or editorial roles, high ethical professional standards, innovation, enthusiasm, strong leadership, and organizational and communication skills to the journal.

The main functions within this role are: strategic and practical development of the journal, defining a vision for the content; defining content and commissioning papers for regular and special issues; maintaining editorial standards; providing strong and inspiring leadership to the journal’s editorial board; appointing new board members to grow the journal; promoting the journal; managing the publication, and working closely with IUBMB and the publisher (Wiley). This important leadership role will require a significant time commitment on a weekly basis and will be recompensed accordingly. Associate Editors are appointed to limited terms by the Editors-in-Chief to handle some functions, subject to approval by the IUBMB Executive Committee. The Editor-in-Chief of Biotechnology and Applied Biochemistry will receive an annual honorarium and is supported by professional editorial office assistance.

Applications should include the following

1. A full CV, including details of peer review and/or editorial roles and the applicant’s publication record
2. A brief statement describing your vision for Biotechnology and Applied Biochemistry
3. A cover letter outlining your suitability for the Editor-in-Chief role
4. Two reference Letters

Please send any queries relating to this appointment and applications, in confidence, to: Prof. James Murphy (jamesm@wehi.edu.au), Chair of the IUBMB Publications Committee. Application deadline October 31, 2024.

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Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 4

If you are learner-centered and you know it, raise your hand: Perspectives on and implementation of pedagogical changes by science instructors during the COVID-19 pandemic

Donham C, Hong H, Signorini A, Menke E, Kranzfelder P. Biochem Mol Biol Educ. 2024; 52(4): 386-402.

Students at Minority-Serving Institutions (MSIs) faced significant hardships while trying to learn through emergency remote teaching (ERT) during the COVID-19 pandemic. This research aims to investigate if science, technology, engineering, and mathematics (STEM) instructors thought about and enacted more learner-centered teaching practices to alleviate some of this stress encountered by their students. Using semi-structured interviews and classroom observations, the authors utilized inductive and deductive qualitative research methods to examine two questions: (1) To what extent were STEM instructor’s perceived pedagogical changes learner-centered during ERT?; and (2) To what extent were STEM instructor’s teaching behaviors and discourse practices learner-centered during ERT?

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Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

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Molecular Aspects of Medicine

Aspects of Molecular Medicine

IUBMB Life
New Issue: Volume 76, Issue 7

Schizosaccharomyces pombe as a fundamental model for research on mitochondrial gene expression: Progress, achievements and outlooks

Dinh N, Bonnefoy N. IUBMB Life. 2024; 76(7): 397-419.

Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial research. The organism resembles human cells in terms of mitochondrial inheritance, mitochondrial transport, sugar metabolism, mitogenome structure and dependence of viability on the mitogenome (the petite-negative phenotype). Here, the authors review the current state of knowledge regarding S. pombe mitochondrial gene expression, and emphasise the pertinence of fission yeast as both a model and tool, especially for studies on mitochondrial translation.
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CALL FOR PAPERS – SPECIAL ISSUES PROPOSALS

IUBMB Life solicits proposals for special issues relevant to the mission of our journal in the field of Biochemistry, Molecular Biology, Cell Biology, Structural Biology and Molecular Medicine and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form available online and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “IUBMB – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue;
• A short introduction about the significance of the special issue;
• Basic information and CV of Lead Guest Editor and Co-Guest Editors;
• List of potential authors and their tentative article titles;
• The estimated number of submissions;
• Proposed timeline.

Please visit the journal homepage for more information.

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BioFactors
New Issue: Volume 50, Issue 3

Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration

Diomede F, Guarnieri S, Lanuti P, Konstantinidou F, Gatta V, Rajan TS, et al. BioFactors. 2024; 50(3): 509–522.

Mesenchymal stem cells (MSCs) are promising for treating heart and vascular diseases, with the potential to differentiate into cardiomyocytes. This study focuses on using extracellular vesicles (EVs) from human dental pulp stem cells (hDPSCs) as a safer and cost-effective alternative to MSCs. The EVs were found to influence cardiomyogenic differentiation by up-regulating key genes like GATA4, ACTC1, CX43, and Nkx2.5. A significant down-regulation of microRNA hsa-miR-200c-3p, which targets GATA4, suggests an epigenetic mechanism at play. The research aims to establish an in vitro model of hDPSCs differentiating into cardiomyocytes, highlighting the potential of EVs from hDPSCs and the HL-1 cell line in this process.

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CALL FOR SPECIAL ISSUE PROPOSALS

BioFactors solicits proposals for special issues relevant to the mission of our journal in the field of biological factors and pertinent areas. This is an open call for Special Issue Proposals, and all submissions will be reviewed in a timely manner. We will provide streamlined editorial support and assistance to the special issue guest editors.

Application Process

Prospective guest editor(s) need to complete the Special Issue Proposal Form (downloadable from the BioFactors’ homepage) and submit it to adaragshet@wiley.com, together with the CV(s) of the proposed guest editor(s). Please state “BIOF – SI proposal submission” in the subject line of your submission email.

A special issue proposal should include the following content:

• A short title that can clearly describe the scope of special issue.
• A short introduction about the significance of the special issue.
• Basic information and CV of Lead Guest Editor and Co-Guest Editors.
• List of potential authors and their tentative article titles.
• The estimated number of submissions.
• Proposed timeline.

Please visit the journal homepage for more information.

Congratulations to the winners!

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Biotechnology and Applied Biochemistry
New Issue: Volume 71, Issue 3

Study of selenium enrichment metabolomics in Bacillus subtilis BSN313 via transcriptome analysis

Ullah A, Yin X, Naveed M, Aslam S, Chan MWH, Bo S, et al. Biotechnol Appl Biochem. 2024; 71: 609–626.

In this study, the transcriptome analysis was practiced to identify potential genes of probiotic Bacillus subtilis BSN313 involved in selenium (Se) enrichment metabolism, and it was concluded that SeMet was the highest content of organic Se byproduct biosynthesized by B. subtilis BSN313 strain in Se-enriched medium during stationary phase. Thus, B. subtilis BSN313 can be considered a commercial probiotic strain that can be used in the food and pharmaceutical industries. This is because it can meet the commercial demand for Se-AAs (SeMet) in both industries

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CALL FOR PAPERS

Leveraging Genomics Data in Blockchain for Medical Research Ethics

The Special Issue aims to create a dialogue on leveraging genomics data in blockchain for medical research ethics. Also, we plan to attract researchers with a diverse range of studies that explore theoretical frameworks, technological innovations, policy analyses, and case studies demonstrating practical applications and challenges.

Topics for this call for papers include but are not restricted to:

• Ethical frameworks for genomic data ownership and sharing on blockchain platforms;
• Technological advancements in secure and scalable blockchain systems for genomic data;
• Interoperability challenges and solutions in integrating genomics with different blockchain architectures;
• Regulatory landscape and policy recommendations for blockchain in genomics;
• Economic models for incentivizing the sharing of genomic data on blockchain platforms;
• Impact assessments of blockchain on the speed and efficacy of medical research;
• Legal implications of decentralized genomic data management;
• Ethical considerations in the use of smart contracts for genomic data consent management;
• Comparative analyses of global initiatives employing blockchain for genomics;
• Challenges and strategies for educating stakeholders about the benefits and risks of blockchain in genomics;
• Future prospects of integrating artificial intelligence with blockchain and genomics for advanced medical research;
• Privacy-preserving techniques for genomic data on blockchain: challenges and future directions;
• Case studies of blockchain applications in enhancing privacy and consent in genomics research.

Deadline for Submissions: 1 December 2024

Guest Editors: Dr Muzammil Hussain (Lead), Pakistan; Dr Muhammad Adnan Khan, Gachon University, The Republic of Korea; Dr Kiran Adnan, Malaysia

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Searching for a New Editor-in-Chief for Biotechnology and Applied Biochemistry

The International Union of Biochemistry and Molecular Biology (IUBMB) seeks a new Editor-in-Chief for Biotechnology and Applied Biochemistry. Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of discoveries in the life sciences that impact and advance biotechnology. The Editor will consider papers for publication based on their potential impact on the field, and their compatibility with journal scope. The journal seeks contributions to the fields of synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology, and how they can be applied to medical and industrial biotechnology.

The successful candidate will be recognized as a leading member of the biochemistry and molecular biology community. They will have an outstanding publication record; an extensive, global network; an appreciation for the diverse fields within the journal’s scope; and will represent the diversity within the IUBMB global community.

The successful candidate will have an outstanding opportunity to further develop the journal over a maximum three 3-year terms in the role commencing July 1, 2025. They must demonstrate a clear vision for its future growth and position in the publishing landscape. The appointee will bring extensive experience in peer review and/or editorial roles, high ethical professional standards, innovation, enthusiasm, strong leadership, and organizational and communication skills to the journal.

The main functions within this role are: strategic and practical development of the journal, defining a vision for the content; defining content and commissioning papers for regular and special issues; maintaining editorial standards; providing strong and inspiring leadership to the journal’s editorial board; appointing new board members to grow the journal; promoting the journal; managing the publication, and working closely with IUBMB and the publisher (Wiley). This important leadership role will require a significant time commitment on a weekly basis and will be recompensed accordingly. Associate Editors are appointed to limited terms by the Editors-in-Chief to handle some functions, subject to approval by the IUBMB Executive Committee. The Editor-in-Chief of Biotechnology and Applied Biochemistry will receive an annual honorarium and is supported by professional editorial office assistance.

Applications should include the following

1. A full CV, including details of peer review and/or editorial roles and the applicant’s publication record
2. A brief statement describing your vision for Biotechnology and Applied Biochemistry
3. A cover letter outlining your suitability for the Editor-in-Chief role
4. Two reference Letters

Please send any queries relating to this appointment and applications, in confidence, to: Prof. James Murphy (jamesm@wehi.edu.au), Chair of the IUBMB Publications Committee. Application deadline October 31, 2024.

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Biochemistry and Molecular Biology Education
New Issue: Volume 52, Issue 4

Use of OneNote class notebook as a combined electronic laboratory notebook and content delivery tool in an introductory biochemistry laboratory course

Khan-Trottier A. Biochem Mol Biol Educ. 2024; 52(4): 462-473.

α-Synuclein (αS) aggregation is the main neurological hallmark of a group of debilitating neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson’s disease is the most prevalent. αS oligomers formed during the initial stages of aggregation are considered key pathogenic drivers of disease onset and progression, standing as privileged targets for therapeutic intervention and diagnosis. In this review, the authors delve into the recent advances in the structural and mechanistic characterization of αS oligomers, and discuss how these advances are transforming our understanding of these elusive species and paving the way for oligomer-targeting therapeutics and diagnosis.

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Did you know? Wiley and Jisc have signed an agreement that allows UK authors to publish Open Access in the IUBMB Journals at no cost to them.

Thanks to a partnership our publisher Wiley has signed with Jisc, certain UK institutions now have full access to journals published by Wiley, including the IUBMB Journals. Further, the partnership enables authors at participating UK institutions to publish open access at no cost to them in the IUBMB Journals. Payment of the associated Article Publication Charges (APC) would be covered via the partnership, and authors will not need to cover the APCs from their own pockets.

Wiley has also signed similar agreements with universities in Germany, the Netherlands, Austria, Norway, Hungary, Finland, Sweden, and with the US-based OhioLink And VIVA. A comprehensive list of our funder agreements can be found here.

Submit your research to the IUBMB Journals today.

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Molecular Aspects of Medicine

Aspects of Molecular Medicine